Clinical and clinicopathologic features of dogs that consumed foodborne hepatotoxic aflatoxins: 72 cases (2005-2006)

Journal of the American Veterinary Medical Association
Diane M DereszynskiSara Y Sanders

Abstract

To characterize clinical signs, clinicopathologic features, treatments, and survival in dogs with naturally acquired foodborne aflatoxicosis. Retrospective case series. 72 dogs that consumed aflatoxin-contaminated commercial dog food. Medical records of affected dogs were reviewed. Between December 2005 and March 2006, dogs were identified as having foodborne aflatoxin hepatotoxicosis on the basis of the history of consumption of contaminated food or characteristic histopathologic lesions (subject dog or a recently deceased dog in the same household or kennel). Recorded information included signalment, clinical features, clinicopathologic test results, treatments, and survival. Data were analyzed by survival status. Most dogs were of large breeds from breeding kennels. No significant differences were found in age or weight between 26 (36%) survivor dogs and 46 (64%) nonsurvivor dogs. Severity of clinical signs varied widely; 7 dogs died abruptly. In order of onset, clinical features included anorexia, lethargy, vomiting, jaundice, diarrhea (melena, hematochezia), abdominal effusion, peripheral edema, and terminal encephalopathy and hemorrhagic diathesis. Common clinicopathologic features included coagulopathic and electrolyte d...Continue Reading

References

Jul 1, 1975·Australian Veterinary Journal·P J KettererM D Connole
Jul 1, 1992·Chemical Research in Toxicology·K D RaneyF Peter Guengerich
Sep 1, 1991·Indian Journal of Pediatrics·H P PatiA K Saraya
Apr 1, 1988·Biochemical Medicine and Metabolic Biology·I U AsuzuO Obidoa
Feb 1, 1970·Food and Cosmetics Toxicology·D S Patterson, R Allcroft
Feb 1, 1995·Pharmacology & Therapeutics·M McLean, M F Dutton
Jan 1, 1994·Annual Review of Pharmacology and Toxicology·D L Eaton, E P Gallagher
Jan 1, 1994·Annual Review of Pharmacology and Toxicology·L W ChangL L Hsieh
Jul 1, 1993·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·S E DeVriesJ C Woo
May 21, 1998·Pharmacology & Therapeutics·M L Clapper
Jul 24, 1998·Mutation Research·F Peter GuengerichS Langouët
Mar 5, 1999·Mutation Research·J S Wang, J D Groopman
Apr 4, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·T K BammlerD L Eaton
Apr 15, 2000·Toxicology and Applied Pharmacology·P SolterR Guzman
Dec 8, 2000·Journal of the American Veterinary Medical Association·Tracy StokolHollis N Erb
Aug 13, 2002·American Journal of Veterinary Research·Sharon A CenterHollis N Erb
Dec 5, 2002·Archives of Biochemistry and Biophysics·F Peter Guengerich
Mar 6, 2003·Human Mutation·Frank StaibCurtis C Harris
Jul 15, 2003·Clinical Microbiology Reviews·J W Bennett, M Klich
Dec 20, 2003·Archives of Toxicology·Toshiyuki WatanabeYoshihiko Ohashi
Mar 23, 2004·The Veterinary Clinics of North America. Small Animal Practice·Sharon A Center
Jun 24, 2004·The American Journal of Clinical Nutrition·Sarah L BoothJeffrey B Blumberg
Sep 24, 2004·Cell Biochemistry and Function·Jasbir SinghPablo Steinberg
Jun 21, 2005·Toxicon : Official Journal of the International Society on Toxinology·P TulayakulS Kumagai
Nov 19, 2005·Chemico-biological Interactions·Diana RingotYvan Larondelle
Mar 6, 2007·The Veterinary Clinics of North America. Small Animal Practice·Sharon A Center
Apr 4, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Shelley Joy NewmanClaudia A Kirk

Citations

Dec 3, 2010·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Wilson K Rumbeiha, Jamie Morrison
Jan 19, 2013·Journal of the South African Veterinary Association·Luke F ArnotChristo J Botha
Apr 26, 2011·Annual Review of Phytopathology·Saori Amaike, Nancy P Keller
Oct 23, 2013·The Veterinary Clinics of North America. Small Animal Practice·Marjory B Brooks, James L Catalfamo
Mar 3, 2012·The Veterinary Clinics of North America. Small Animal Practice·Karyn Bischoff, Wilson K Rumbeiha
Aug 31, 2011·Research in Veterinary Science·Y BruchimI Aroch
Feb 10, 2012·Journal of Veterinary Emergency and Critical Care·Carrie KavanaghCynthia R L Webster
Feb 9, 2010·The Journal of Small Animal Practice·C ElwoodK Savary-Bataille
Apr 18, 2015·Journal of Veterinary Emergency and Critical Care·Molly A Weingarten, Allison A Sande
Jul 17, 2015·Journal of Veterinary Internal Medicine·D KelleyCynthia R L Webster
Jul 5, 2015·Neurotoxicology·Fatima TrebakRabia Magoul
Jun 7, 2011·Toxicology Letters·Marcin RatajewskiJarosław Dastych
Sep 12, 2013·Fungal Genetics and Biology : FG & B·Gregory M Gauthier, Nancy P Keller
May 6, 2016·Journal of Veterinary Emergency and Critical Care·Carrie LesterCynthia R L Webster
Feb 21, 2014·Veterinary Pathology·P V TurnerL M Wancket
Jan 10, 2017·The Veterinary Clinics of North America. Small Animal Practice·Vincent Thawley
Dec 12, 2017·Journal of the South African Veterinary Association·Sanil D SinghAnil A Chuturgoon
Mar 8, 2019·Journal of Veterinary Internal Medicine·Cynthia R L WebsterPenny J Watson
Aug 20, 2019·Journal of Complementary & Integrative Medicine·A S AkinrindeA Asekun
Nov 12, 2019·Journal of Feline Medicine and Surgery·Claudia BowmanJean-Sébastien Palerme
Aug 26, 2020·Australian Veterinary Journal·B B LakeL Scott
Oct 19, 2017·Journal of the South African Veterinary Association·Sanil D Singh, Anil A Chuturgoon
Dec 23, 2018·Journal of Veterinary Internal Medicine·Peter H KookMaja Ruetten
Oct 15, 2019·The Journal of Small Animal Practice·R BirkbeckS Cortellini
Dec 7, 2018·Journal of Veterinary Emergency and Critical Care·Christine GriebschPeter Bennett
Jan 21, 2021·Toxins·Lizbeth Martínez-MartínezRaúl Ortiz-Martínez
Apr 12, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xue XuJianxin Chen

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