Clinical and clinicopathological characteristics of acute lymphoblastic leukaemia in six cats

The Journal of Small Animal Practice
H TomiyasuH Tsujimoto

Abstract

To investigate the clinical characteristics of feline acute lymphoblastic leukaemia patients diagnosed according to the recent diagnostic criteria for the equivalent canine condition. The medical records of six cats diagnosed with acute lymphoblastic leukaemia were retrospectively reviewed to extract data on clinicopathological characteristics and outcomes. The lymphoid origin of the tumour cells was confirmed by polymerase chain reaction for antigen receptor gene rearrangement, flow cytometry or immunohistochemistry. Non-specific clinical signs such as lethargy and anorexia were common, and anaemia and thrombocytopenia were also commonly identified. Leucocytosis was observed in four cats and leucopenia was observed in two; the number of lymphoblasts in the peripheral blood samples varied among the cases. Lymphoblasts originated from B-cell lineage in four cats and T-cell lineage in one, and those of another cat were positive for both B-cell marker CD21 and T-cell marker CD8. Five of the six cats were treated with cytotoxic chemotherapy, and a partial response was obtained in two. The median overall survival was 55 days (range: 1 to 115). Acute lymphoblastic leukaemia should be considered if lymphoblasts are observed in periphe...Continue Reading

References

Jun 28, 2011·Veterinary Immunology and Immunopathology·Hiroyuki MochizukiHajime Tsujimoto
Jan 21, 2012·Veterinary Immunology and Immunopathology·Hiroyuki MochizukiHajime Tsujimoto
Jan 28, 2015·Veterinary and Comparative Oncology·M NovaccoV Martini
Jul 13, 2016·Veterinary and Comparative Oncology·A L BennettP R Hess

❮ Previous
Next ❯

Citations

Nov 7, 2019·Journal of Veterinary Internal Medicine·Emily D RoutPaul R Avery
Apr 29, 2021·Journal of Feline Medicine and Surgery·Barbara C RütgenIlse Schwendenwein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

The Journal of Veterinary Medical Science
Akihisa Suwa, Tetsuya Shimoda
Clinical and Experimental Immunology
K J Gajl-PeczalskaJ H Kersey
Veterinary Clinical Pathology
Liana GranumWilliam Vernau
© 2022 Meta ULC. All rights reserved