Clinical and dosimetric factors associated with acute rectal toxicity in patients treated with (131)Cs brachytherapy for prostate cancer

Brachytherapy
A S GokhaleRonald M Benoit

Abstract

(131)Cs has been recently introduced for use in prostate brachytherapy. We wished to identify clinical and dosimetric factors associated with acute bowel/rectal toxicity in patients treated with (131)Cs. Patients treated with (131)Cs prostate brachytherapy at the University of Pittsburgh were asked to complete expanded prostate cancer index composite surveys preoperatively and at 2-4 weeks and 3 months postimplant. We identified patients who experienced acute and persistent acute bowel toxicity to determine if any factors could correlate with either situation. One hundred six patients were treated with (131)Cs from September 2006 to May 2008. Thirty-eight percent of patients met our criteria for patient-appreciated acute bowel symptoms. On multivariate analysis, the volume of rectum receiving 50% of the prescribed dose (R-V(50); 4.1 vs. 2.6cc, p=0.01), R-V(75) (1.3 vs. 0.62cc, p=0.01), the percentage of the prescribed dose received by 1cc of the rectum (R-D-1cc; 75% vs. 64%, p=0.02), and R-D-2cc (63% vs. 54%, p=0.003) were found to be factors associated with a greater risk of severe acute bowel toxicity. At 3-month followup, 28% of patients had persistent acute bowel toxicity. On multivariate analysis, no factors were identifie...Continue Reading

References

Oct 19, 1999·International Journal of Radiation Oncology, Biology, Physics·F M Waterman, A P Dicker
Oct 6, 2000·International Journal of Radiation Oncology, Biology, Physics·G S MerrickJ H Lief
Nov 7, 2000·Cancer·D TheodorescuP G Koutrouvelis
May 15, 2002·International Journal of Radiation Oncology, Biology, Physics·Song K KangMitchell S Anscher
Jan 16, 2003·International Journal of Radiation Oncology, Biology, Physics·Frank M Waterman, Adam P Dicker
Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Gregory S MerrickZachariah Allen
Aug 23, 2005·International Journal of Radiation Oncology, Biology, Physics·Audrey TranWayne Butler
May 4, 2007·The Cancer Journal·Gregory S MerrickJonathan Lief
Nov 6, 2007·International Journal of Radiation Oncology, Biology, Physics·Z Jay ChenRavinder Nath
Apr 1, 2008·American Journal of Surgery·Richard N LesperanceScott R Steele

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Citations

Mar 23, 2012·The Spine Journal : Official Journal of the North American Spine Society·Jorrit-Jan VerlaanMarco van Vulpen
Feb 4, 2012·International Journal of Radiation Oncology, Biology, Physics·Vedang MurthyShyamkishore Shrivastava

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