Clinical and echographic characteristics of patients exposed to fenfluramin or its derivatives: Results of a prospective, single-centre, observational study

Archives of Cardiovascular Diseases
David Cambon, Florence Leclercq

Abstract

Fenfluramine and its derivatives have been associated with significant risk of developing valvular heart disease but its exact prevalence and severity are still debated. To evaluate the clinical and echocardiographic characteristics of patients hospitalized in a cardiology centre and who had past exposure to these drugs. Between July 2011 and February 2012, patients admitted to the hospitalization and intensive care units at the University Centre of Montpellier, France were questioned about past exposure to fenfluramine or its derivatives. In patients who reported exposure, a questionnaire assessing prescribing patterns and medical history was proposed and echocardiography performed. All of the usual echocardiographic variables were analysed. We applied criteria from a French multicentre registry for diagnosis of drug-induced valvulopathy: leaflets and subvalvular apparatus thickening and retraction, leaflets loss of coaptation, no calcification, and no stenosis. Ninety-five patients exposed to these drugs were included. The majority were female (n=62, 65.3%), 53.2% (n=50) had diabetes and 90.5% (n=86) were exposed to benfluorex. Mean treatment duration was 52.3months (95% confidence interval [CI] 39.0-65.6). Valvular regurgita...Continue Reading

References

Dec 10, 1999·Journal of the American College of Cardiology·N J WeissmanJ T Gwynne
Jul 2, 2003·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·William A ZoghbiUNKNOWN American Society of Echocardiography
Mar 3, 2009·The European Respiratory Journal·K BoutetM Humbert
Apr 21, 2010·PloS One·Irène FrachonChristophe Leroyer
Jun 1, 2010·Journal of the American College of Cardiology·George ThanassoulisSekar Kathiresan
Oct 15, 2010·Pharmacoepidemiology and Drug Safety·Alain WeillHubert Allemand

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