Clinical and economic burden of adverse drug reactions

Journal of Pharmacology & Pharmacotherapeutics
Janet SultanaGianluca Trifirò

Abstract

Adverse drug reactions (ADRs) are unwanted drug effects that have considerable economic as well as clinical costs as they often lead to hospital admission, prolongation of hospital stay and emergency department visits. Randomized controlled trials (RCTs) are the main premarketing methods used to detect and quantify ADRs but these have several limitations, such as limited study sample size and limited heterogeneity due to the exclusion of the frailest patients. In addition, ADRs due to inappropriate medication use occur often in the real world of clinical practice but not in RCTs. Postmarketing drug safety monitoring through pharmacovigilance activities, including mining of spontaneous reporting and carrying out observational prospective cohort or retrospective database studies, allow longer follow-up periods of patients with a much wider range of characteristics, providing valuable means for ADR detection, quantification and where possible reduction, reducing healthcare costs in the process. Overall, pharmacovigilance is aimed at identifying drug safety signals as early as possible, thus minimizing potential clinical and economic consequences of ADRs. The goal of this review is to explore the epidemiology and the costs of ADRs ...Continue Reading

Citations

Jul 6, 2014·Expert Opinion on Drug Metabolism & Toxicology·Mark J Canet, Nathan J Cherrington
Aug 30, 2014·Expert Opinion on Drug Safety·Christian LeporiniEmilio Russo
Aug 1, 2014·Pharmacoepidemiology and Drug Safety·Charles HengBruno Michel
Apr 24, 2014·Journal of Nursing Management·Sue Jordan, Una Kyriacos
May 15, 2015·Journal of Nursing Management·Alessia De AngelisRosaria Alvaro
May 2, 2015·Pharmacogenomics·Jeremy R Everett
Mar 31, 2015·Critical Care Clinics·Omar Badawi, Erkan Hassan
Sep 1, 2016·European Journal of Human Genetics : EJHG·Ritika KapoorYik-Ying Teo
Sep 20, 2016·British Journal of Clinical Pharmacology·Sze Ling ChanAlexandre Chan
Nov 7, 2016·Trends in Pharmacological Sciences·Thomas M Kuntz, Jack A Gilbert
Nov 25, 2016·Basic & Clinical Pharmacology & Toxicology·Tim SchutteUNKNOWN Education Committee/Working Group Research in Education of the Dutch Society of Clinical Pharmacology and Biopharmacy (NVKF&
Jan 28, 2017·Journal of Nursing Management·Alessia De AngelisErcole Vellone
Jan 26, 2017·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Tim SchutteMichiel A van Agtmael
Apr 5, 2018·Bioinformatics·Aleksandar Poleksic, Lei Xie
May 8, 2018·Journal of Clinical Pharmacology·Ar Kar AungLinda Velta Graudins
May 1, 2018·Protein & Cell·Marwah DoestzadaJingyuan Fu
Nov 17, 2017·BMC Pharmacology & Toxicology·Silvana Maria de AlmeidaMichael B Edmond
Dec 19, 2017·International Journal of Clinical Pharmacy·Shaimaa ElshafieAnne Marie Roberti
Dec 6, 2017·Therapeutic Advances in Drug Safety·Jiaheng XieZachary A Marcum
Nov 22, 2017·Antimicrobial Agents and Chemotherapy·Jolene K BergStephen Villano
Aug 2, 2017·PloS One·Paulo Henrique Santos AndradeWellington Barros da Silva
Oct 28, 2018·International Journal of Clinical Pharmacy·Faizan MazharCarla Carnovale
Jan 9, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Janet SultanaGianluca Trifiro'
Oct 3, 2017·Briefings in Bioinformatics·Emir MuñozPierre-Yves Vandenbussche
Jan 25, 2019·Journal of Pain & Palliative Care Pharmacotherapy·Jordan O'LearyTodd Brothers
Oct 26, 2018·Cell Biology and Toxicology·A Marcell SzaszGyörgy Marko-Varga
Oct 23, 2016·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Gary R MatzkeL David Harlow
Apr 13, 2019·Future Oncology·Balkees Abderrahman
Nov 6, 2018·Current Drug Targets·Surovi SaikiaRajeev Sarmah
Apr 3, 2019·Clinical Pharmacology and Therapeutics·Anukriti SharmaJack A Gilbert
Jul 17, 2019·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Gillian A BeauchampUNKNOWN Toxicology Investigators Consortium (ToxIC)
Oct 17, 2019·Clinical Pharmacology and Therapeutics·Anukriti SharmaJack A Gilbert

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BETA
hormone replacement therapy
pharmacotherapy

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