Clinical and economic burden of extra-articular manifestations in ankylosing spondylitis patients treated with anti-tumor necrosis factor agents

Journal of Medical Economics
Xin GaoMary Cifaldi

Abstract

To assess concomitant extra-articular manifestation (EAM) rates in patients with ankylosing spondylitis (AS) treated with anti-tumor necrosis factor (anti-TNF) agents and examine the economic burden of uveitis and inflammatory bowel disease (IBD) in French and German AS patients. Previous analyses of uveitis and IBD in AS patients treated with infliximab, etanercept or adalimumab were identified in PubMed/Medline (January 2000 to August 2011). A supplemental analysis incorporated more recent adalimumab clinical trial data (ATLAS [NCT00085644] and RHAPSODY [NCT00478660]). For resource utilization/costs associated with EAMs, the search was expanded to general spondyloarthritis (SpA) conditions (i.e., AS, reactive or psoriatic arthritis, psoriatic spondylitis, IBD and undifferentiated SpA). Direct and indirect yearly costs associated with AS-associated uveitis and IBD were estimated based on interviews with French and German clinicians and literature review. The pooled average rate of anterior uveitis (AU) flares for patients treated with anti-TNF therapy in two meta-analyses and supplemental adalimumab clinical trials was 4.9/100-patient-years (PYs). AU rates (per 100-PYs) were 3.4, 3.7 and 5.7 for infliximab (p=0.26 vs etanercep...Continue Reading

References

Feb 22, 2001·Seminars in Arthritis and Rheumatism·F Hamideh, P E Prete
Apr 19, 2002·The Journal of Pharmacology and Experimental Therapeutics·Bernie ScallonCarrie Wagner
May 3, 2002·The New England Journal of Medicine·Jennifer D GormanJohn C Davis
Oct 31, 2002·Best Practice & Research. Clinical Rheumatology·Dominique BaetenEric M Veys
Jul 16, 2003·Annals of the Rheumatic Diseases·A BoonenSj van der Linden
Sep 4, 2004·Annals of the Rheumatic Diseases·A CalinS Fatenejad
May 3, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Annette LöschMatthias Becker
Sep 9, 2005·European Journal of Gastroenterology & Hepatology·Derek P JewellScot Buchan
Feb 18, 2006·Dermatology : International Journal for Clinical and Investigative Dermatology·S SohnM Augustin
Jun 2, 2006·Rheumatology International·Alessandro VolpeDomenico Biasi
Aug 11, 2006·PharmacoEconomics·Renee StarkReiner Leidl
Sep 6, 2006·Gastroenterology·Selwyn OdesUNKNOWN European Collaborative Study on Inflammatory Bowel Disease
Jul 21, 2007·Seminars in Arthritis and Rheumatism·Beni Grinblat, Morton Scheinberg
Mar 11, 2008·Joint, Bone, Spine : Revue Du Rhumatisme·Daniel WendlingFrançois Aubin
Jul 17, 2008·BMC Ophthalmology·Antoine Lafuma, Gilles Berdeaux
Sep 24, 2008·The British Journal of Dermatology·A LloydG Baxter
May 26, 2009·Annals of the Rheumatic Diseases·J SieperB Freundlich
Jan 16, 2010·Health Economics·Julia BonastreGerard de Pouvourville
Mar 2, 2010·Clinics in Orthopedic Surgery·Jung-Hwan Son, Sang-Won Cha
May 5, 2011·Annals of the Rheumatic Diseases·J BraunD van der Heijde
Aug 25, 2011·Seminars in Arthritis and Rheumatism·Daniel WendlingUNKNOWN CRI

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Citations

Dec 25, 2015·The New England Journal of Medicine·Dominique BaetenUNKNOWN MEASURE 2 Study Group
Aug 4, 2015·Current Rheumatology Reports·Muhammad A KhanJames T Rosenbaum
Oct 23, 2015·Reumatología clinica·Alfredo Manuel Adán-CiveraAntonio Bañares-Cañizares
Dec 10, 2014·Best Practice & Research. Clinical Rheumatology·Enrique Roberto SorianoLiron Caplan
Mar 1, 2019·International Journal of Rheumatic Diseases·Lai Shan TamChak Sing Lau
Jan 17, 2020·International Journal of Rheumatic Diseases·Hakan ApaydinŞükran Erten
Nov 2, 2019·Bone Research·Wei ZhuXisheng Weng
Jun 20, 2020·Expert Opinion on Drug Metabolism & Toxicology·Francesca MarinoFabiola Atzeni
Jul 23, 2021·Therapeutic Advances in Musculoskeletal Disease·Elsa How Shing KoyYves-Marie Pers

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