Clinical and economic burden of pneumococcal disease in US adults aged 19-64 years with chronic or immunocompromising diseases: an observational database study

BMC Infectious Diseases
Dongmu ZhangXiaoqin Yang

Abstract

Despite the widespread availability of pneumococcal vaccines, rates of pneumococcal disease are disproportionately high in adults with chronic and immunocompromising conditions. This study investigated pneumococcal disease rates and associated resource utilization and costs in this group. A retrospective, observational study was conducted using the Truven Health MarketScan® Commercial Claims and Encounters database. The study population was adults aged 19-64 years with continuous health plan enrollment for at least one year before and at least one day after January 1st 2012, 2013 and/or 2014. Medical conditions were identified using ICD-9-CM diagnosis codes and grouped into at-risk (chronic) and high-risk (immunocompromising) conditions. Pneumococcal disease was stratified into all-cause pneumonia (ACP) and invasive pneumococcal disease (IPD). Thirty-six million adults aged 19-64 years were included in the study. 17% had a condition that put them at increased risk for pneumococcal disease. Rates of ACP and IPD in adults with at-risk conditions were 3.6 and 4.6 times the rate in healthy adults, respectively, and 5.3 and 10.5 for adults with high-risk conditions. Risk was particularly high in adults with ≥2 medical conditions: ra...Continue Reading

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Citations

Sep 2, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Robert Root-Bernstein
Jul 28, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Donald HurleyWendy Watson
May 16, 2020·F1000Research·Charles Feldman, Ronald Anderson
Nov 2, 2019·Infectious Disease Clinics of North America·Deirdre Fitzgerald, Grant W Waterer
Mar 23, 2021·Infectious Diseases and Therapy·Abdul Rahman BizriHammam Haridy
Feb 6, 2022·Journal of the American Geriatrics Society·Lauren J HuntAlexander K Smith

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