Clinical and economic impact of infusion reactions in patients with colorectal cancer treated with cetuximab.

Annals of Oncology : Official Journal of the European Society for Medical Oncology
K A FoleyZ Zhao

Abstract

Systemic agents in cancer treatment were often associated with possible infusion reactions (IRs). This study estimated the incidence of IRs requiring medical intervention and assessed the clinical and economic impacts of IRs in patients with colorectal cancer (CRC) treated with cetuximab. Details on patients with CRC receiving cetuximab in 2004-2006 were extracted from a large USA administrative claims database. IRs were identified based on the occurrence of outpatient treatment, emergency room (ER) visit, and/or hospitalization for hypersensitivity and allergic reactions. Multivariate regressions were used to examine potential risk factors and quantify the economic impact of IRs. A total of 1122 CRC patients receiving cetuximab were identified. The incidence of IRs requiring medical intervention was 8.4%. Sixty-eight percent of the patients had treatment disruptions and 34% discontinued cetuximab treatment. Mean adjusted costs were $13,863 for cetuximab administrations with an IR requiring ER visit or hospitalization and $6280 for those with an IR requiring outpatient treatment, compared with $4555 for those without an IR. The incidence rate of cetuximab-related IRs requiring medical intervention in clinical practice was found...Continue Reading

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Citations

Dec 6, 2011·Cancer Immunology, Immunotherapy : CII·Martin H Bluth
Jul 8, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S MaierK P Sugarman
Jan 18, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G ReschJ Thaler
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Apr 2, 2011·The Journal of Allergy and Clinical Immunology·Scott P ComminsThomas A E Platts-Mills
Jun 26, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Kathy L SchulmanAlex Shteynshlyuger
Jun 22, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maria Chiara TronconiArmando Santoro
Nov 19, 2013·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Karen KeatingJared Weiss
Jun 28, 2012·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Shkun ChaddaNils-Olof Bengttson
Nov 9, 2012·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Sarah HoppsEmily Borders
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Apr 6, 2013·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Keith Dawson
Nov 22, 2018·Cost Effectiveness and Resource Allocation : C/E·Yifan XuAfsaneh Barzi
Mar 28, 2019·Journal of Managed Care & Specialty Pharmacy·Sarah HollmannEric M Maiese
Oct 30, 2020·Journal of Comparative Effectiveness Research·Francois-Xavier LamyChris P Pescott

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