Clinical and Economic Outcomes in Low-risk Pulmonary Embolism Patients Treated with Rivaroxaban versus Standard of Care

Journal of Health Economics and Outcomes Research
W Frank PeacockConcetta Crivera

Abstract

Rivaroxaban, a fixed-dose oral direct factor Xa inhibitor, does not require continuous monitoring and thus reduces the hospital stay and economic burden in low-risk pulmonary embolism (LRPE) patients. Study Question: What is the effectiveness of rivaroxaban versus the standard of care (SOC; low-molecular-weight heparin, unfractionated heparin, warfarin) among LRPE patients in the Veterans Health Administration? Adult patients with continuous health plan enrollment for ≥12 months pre- and 3 months post-inpatient PE diagnosis (index date=discharge date) between October 1, 2011-June 30, 2015 and an anticoagulant claim during the index hospitalization were included. Patients scoring 0 points on the simplified Pulmonary Embolism Stratification Index were considered low-risk and were stratified into SOC and rivaroxaban cohorts. Propensity score matching (PSM) was used to compare hospital-acquired complications (HACs), PE-related outcomes (recurrent venous thromboembolism, major bleeding, and death), and healthcare utilization and costs between the rivaroxaban and SOC cohorts. Among 6746 PE patients, 1918 were low-risk; of these, 73 were prescribed rivaroxaban, 1546 were prescribed SOC, and 299 were prescribed other anticoagulants dur...Continue Reading

References

Apr 29, 2004·Diabetes Care·Charles Maynard, Michael K Chapko
Sep 27, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·D L TirschwellW T Longstreth
Aug 4, 2009·Vascular Health and Risk Management·Luca MasottiPatrick Ray
Mar 17, 2010·Journal of Thrombosis and Haemostasis : JTH·M J AgterofD H Biesma
Aug 27, 2011·Stroke; a Journal of Cerebral Circulation·Annette IngemanSøren P Johnsen
Mar 28, 2012·The New England Journal of Medicine·Harry R BüllerAnnelise Segers
May 3, 2014·Journal of the American Geriatrics Society·Partha SardarGregory Y H Lip
Feb 27, 2015·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Gregory J FermannAnthonie W A Lensing
Jul 5, 2015·International Journal of Cardiology·Kristian HellenkampMareike Lankeit
Feb 27, 2016·Critical Care Nursing Quarterly·Parth RaliKhalid Malik
Nov 1, 2016·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Adam J SingerW Frank Peacock
Jun 14, 2018·Health Services Research·Mary Vaughan SarrazinCarolyn L Turvey

❮ Previous
Next ❯

Software Mentioned

SAS
MERCURY

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The New England Journal of Medicine
Pierre-Géraud ClaretJean-Emmanuel de la Coussaye
The New England Journal of Medicine
Dearbhaile M O'DonnellJames S O'Donnell
The New England Journal of Medicine
Emmanuel Bhaskar
© 2021 Meta ULC. All rights reserved