Clinical and economic outcomes in patients switched to simvastatin in a community-based family medicine practice

International Journal of Clinical Practice
V J WilleyM J Cziraky

Abstract

The introduction of a generic formulation of simvastatin has created the potential to provide significant low-density lipoprotein cholesterol (LDL-C) reduction in a highly cost-effective manner. This retrospective cohort analysis utilised electronic medical record data from a United States, community-based, independent physician family medicine practice. Patients switched from other statins or statin combinations to simvastatin by the family medicine physicians during routine patient care from January 2002 to October 2008 were identified. Equivalent statin dosing, lipid panel changes and National Cholesterol Education Program--Adult Treatment Panel III (NCEP) LDL-C goal attainment rates were compared preswitch and postswitch. The potential economic impact of simvastatin switching was also evaluated. A total of 78 patients were identified, and in 76.9% of the switches, an equipotent dose of simvastatin was prescribed. All lipid fractions showed small, non-significant increases, with LDL-C having a 2.2 mg/dl (0.06 mmol/l) increase after switching (p = 0.476). NCEP LDL-C goal attainment rates were 79.5% and 78.2% before and after switching, respectively (p = 1.00). Modelled annual cost savings associated with switching were estima...Continue Reading

References

Feb 25, 2000·Journal of Cardiovascular Pharmacology and Therapeutics·M FarnierP Maigret
Jul 16, 2003·The American Journal of Cardiology·Peter H JonesUNKNOWN STELLAR Study Group
Nov 15, 2006·Clinical Transplantation·Bengt FellströmUNKNOWN Assessment of Lescol in Renal Transplantation (ALERT) study group

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Citations

Nov 19, 2011·International Journal of Clinical Practice·M C S WongK S D Liu
Oct 16, 2012·The Journal of Cardiovascular Nursing·Peter W KakavasHeather Sell
Oct 21, 2010·Expert Opinion on Pharmacotherapy·Vasilios G AthyrosDimitri P Mikhailidis

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