Clinical and Electroencephalographic (EEG) Features Associated With Refractoriness in Benign Childhood Epilepsy With Centrotemporal Spikes

Journal of Child Neurology
Fenglai XiaoDong Zhou

Abstract

The aim of this study is to identify clinical or electroencephalographic (EEG) features associated with refractoriness to the initial antiepileptic drug in typical benign childhood epilepsy with centrotemporal spikes. A total of 87 children with typical benign childhood epilepsy with centrotemporal spikes were retrospectively reviewed in the analyses. The patients were subdivided into 2 groups: patients whose seizures were controlled with monotherapy and patients requiring 2 medications. Sixty-three children achieved seizure freedom with monotherapy, whereas 24 received 2 medications for seizure control. Diffusing foci at the follow-up EEG and delayed treatment (duration >1 year) are 2 main risk factors associated with more refractory cases (P < .001). Delayed diagnosis (37.1%) and nonadherence to treatment (57.2%) contributed to delayed treatment. Our findings suggested that diffusing foci on EEG and delayed treatment are associated with more frequent seizures and refractoriness in benign childhood epilepsy with centrotemporal spikes. Diagnostic delays and nonadherence hindered timely care, which may represent opportunities for improved intervention.

References

Feb 14, 2006·Lancet·Renzo Guerrini
Jun 30, 2006·Brain & Development·Xiuhe ZhaoXuewu Liu
Aug 18, 2009·Epilepsia·Natalio Fejerman
Aug 26, 2009·Epilepsia·W Donald Shields, Orlando Carter Snead
Jun 19, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Renzo GuerriniAnna Rosati
Sep 14, 2012·Epilepsia·Renzo Guerrini, Simona Pellacani
Feb 11, 2014·Seizure : the Journal of the British Epilepsy Association·Jia HuXiao-Fang Chen

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Citations

Mar 18, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Chunrong LiuJiwen Wang
Mar 17, 2021·Seizure : the Journal of the British Epilepsy Association·Hasan TekgulSanem Yılmaz

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