Clinical and endocrine effects of a microdose GnRH agonist flare regimen administered to poor responders who are undergoing in vitro fertilization

Fertility and Sterility
Eric S SurreyM W Surrey

Abstract

To assess the endocrine and clinical responses to microdose GnRH agonist (GnRH-a) that was administered in the early follicular phase before controlled ovarian hyperstimulation to poor responders who were candidates for IVF-ET. Prospective nonrandomized trial with historical controls. Tertiary care university-affiliated infertility practice. Thirty-four IVF-ET candidates with a prior poor response to a standard long-protocol GnRH-a controlled ovarian hyperstimulation regimen (cycle A). Patients were divided into two groups based on their age at the initiation of cycle A (Group 1: < or = 39 years, n = 15; Group 2: > or = 40 years, n = 19). Low-dose oral contraceptive (x 21 d) followed by GnRH-a (leuprolide acetate; 40 micrograms s.c. b.i.d.) flare and urofollitropin initiated on day 3 of GnRH-a administration (cycle B). Comparative analysis of clinical responses (total urofollitropin dose used and number of oocytes retrieved as well as fertilization and clinical and ongoing pregnancy rates) and endocrine responses (serum E2, FSH, LH, T, and P levels) between cycles A and B in the two groups. Early follicular phase serum E2 and FSH changes in groups 1 and 2 were compared with changes in nine normal responder controls who were rec...Continue Reading

Citations

Sep 17, 2009·Archives of Gynecology and Obstetrics·Tevfik Yoldemir, Ian S Fraser
Apr 23, 2005·Journal of Assisted Reproduction and Genetics·Shai E ElizurJehoshua Dor
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Nov 30, 2007·Journal of Assisted Reproduction and Genetics·Eric S Surrey
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