Clinical and epidemiological characteristics of subacute sclerosing panencephalitis in Bulgaria during the past 25 years (1978-2002)

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society
V BojinovaMaria T Hristova

Abstract

The aims of the present study are to establish the subacute sclerosing panencephalitis (SSPE) incidence in Bulgaria for the 25-year period 1978-2002; to analyze the SSPE incidence prior to, and in the period of, routine measles immunization; and, to analyze the clinical characteristics of SSPE. SSPE was diagnosed in a total of 40 children; 28 of were diagnosed between 1978 and 1984, and 12 between 1995 and 2002. Thirty-eight cases (95%) were non-immunized and have had an early measles infection (mean age 16 months). The SSPE onset occurred primarily between 8 and 11 years of age (52.5%) with a mean latent period of about 7 years after the measles infection. After the 10-year disease-free period (1985-1994), the SSPE incidence increased between 1995 and 2002 because of the 1991-1992 measles epidemic. During the period 1995-2002 children with earlier measles infection and earlier SSPE onset predominated, compared to the period 1978-1984. The initial clinical manifestations included intellectual deterioration in 35%, extrapyramidal hyperkinesias in 29%, epileptic seizures in 15%, hemiparesis in 10%, and visual disturbances in 10% of the cases. Nine children (22.5%) demonstrated an atypical onset. A rapidly progressive course was o...Continue Reading

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Citations

Jan 5, 2007·Indian Journal of Pediatrics·Serdar ComertYasemin Akin
Nov 27, 2007·International Journal of Epidemiology·H CampbellE Miller
Oct 7, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Michael K Lo, Paul A Rota
Dec 21, 2007·Arquivos de neuro-psiquiatria·Marcelo Maroco CruzeiroGláucio Mendes Franco
Aug 19, 2007·Annals of Neurology·James J SejvarStephen P Luby
Sep 9, 2005·The Pediatric Infectious Disease Journal·Serdal GüngörDave A Harbour
Mar 12, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Mark MuscatMira Kojouharova
Aug 8, 2015·Risk Analysis : an Official Publication of the Society for Risk Analysis·Kimberly M ThompsonRobert T Perry
May 3, 2005·Current Opinion in Infectious Diseases·David Elliman, Nitu Sengupta

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