Clinical and epidemiological features of acute lymphoblastic leukemia following a previous malignancy

Leukemia & Lymphoma
L PaganoG Leone

Abstract

Secondary malignancies represent a relevant complication of chemotherapy employed for a previous cancer. Acute leukemias represent the most frequent secondary malignancy in the first decade following primary neoplasms; secondary leukemias are generally myeloid and can be preceeded by a myelodysplastic syndrome. The biological and epidemiological characteristics of secondary acute myeloid are well known and have been the subject of numerous reports and reviews in the last few years. The observation of a secondary acute lymphoblastic leukemia is considered rare, and the correlation with antecedent therapies is not definitive. Most of reported cases are single reports, and no large study has been performed to investigate the real importance of this problem. In this review we report data of the current literature on secondary acute lymphoblastic leukemia, both in adults and children, in order to analyze its incidence and clinical and laboratory features.

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Citations

Mar 10, 2005·Journal of Clinical Laboratory Analysis·Roger S RileyJonathan M Ben-Ezra
Mar 21, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Fariba NavidCarlos Rodriguez-Galindo
May 15, 2009·British Journal of Haematology·John M StorringJoseph M Brandwein
Sep 30, 2003·Medical and Pediatric Oncology·Takashi MiyagiMasato Masuda
Jul 7, 2010·The Korean journal of laboratory medicine·Jinhee ChoHong Ghi Lee
Jan 18, 2011·The Korean journal of laboratory medicine·Byong-Joon YooSoo-Young Yoon

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