Clinical and functional significance of STEAP4-splice variant in CD14+ monocytes in patients with rheumatoid arthritis

Clinical and Experimental Immunology
H EbeTakayuki Sumida

Abstract

Tumour necrosis factor alpha (TNF)-α-induced adipose-related protein (TIARP) is a negative regulator of inflammation in arthritis model mice. In humans, six-transmembrane epithelial antigen of prostate 4 (STEAP4) (human counterpart of TIARP) is also expressed in CD14+ monocytes from patients with rheumatoid arthritis (RA). Recently, highly levels of exon 3-spliced variant STEAP4 (v-STEAP4) expression have been observed in porcine lung. The aim of this study is to elucidate the expression and functional role of v-STEAP4, comparing it with that of STEAP4, in the pathogenesis of arthritis. We identified v-STEAP4 in CD14+ cells. The expression of STEAP4 and v-STEAP4 was higher in patients with RA than in healthy participants. We also found that STEAP4 and v-STEAP4 were correlated positively with C-reactive protein and that their expression was decreased after treatment with an interleukin (IL)-6 antagonist in patients with RA. To investigate further the role of STEAP4 and v-STEAP4, we produced STEAP4 and v-STEAP4 over-expressing human monocytic cell lines (THP-1) for functional analysis. In the v-STEAP4 over-expressing cells, the production of IL-6 was suppressed significantly, but TNF-α was increased significantly through lipopoly...Continue Reading

References

Jan 20, 2005·Gene·Stefan StammHermona Soreq
May 26, 2007·Nature Reviews. Immunology·Iain B McInnes, Georg Schett
May 26, 2007·Nature Reviews. Immunology·Akihiko YoshimuraMasato Kubo
Dec 29, 2007·The Journal of Pathology·J R Bradley
Jan 11, 2008·The Journal of Investigative Dermatology·Bing-Mei ZhuLothar Hennighausen
Jul 23, 2013·Patient Preference and Adherence·Israa Al-ShakarchiDavid L Scott
Apr 8, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Isao MatsumotoTakayuki Sumida

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Citations

Aug 9, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Lei LiuChunying Jiang
Oct 10, 2021·Annals of the Rheumatic Diseases·Alejandro Ibáñez-CostaChary Lopez-Pedrera

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