Clinical and genetic analysis of noncancerous and cancerous biliary epithelium in patients with pancreaticobiliary maljunction

World Journal of Surgery
Moritaka NagaiShuji Isaji

Abstract

We analyzed clinical features and genetic alterations in the noncancerous and cancerous biliary lesions obtained from pancreaticobiliary maljunction (PBM) patients. Gallbladder (GB) and bile duct (BD) lesions were obtained surgically from 36 patients with PBM, and polymerase chain reaction (PCR) methods were used to examine for mutations of the K-ras gene and the p53 gene and for microsatellite instability (MSI). The 36 cases were clinically classified into two types according to whether extrahepatic bile duct dilatation was present: a congenital choledochal dilatation (CCD) group (n = 20) and a noncongenital choledochal dilatation (NCCD) group (n = 16). In the NCCD group, all 16 GB specimens exhibited hyperplastic, dysplastic, and cancerous (n = 9) lesions, but no pathological lesions were detected in the 12 BD specimens. On the other hand, in the CCD group, pathological examination revealed lesions, including 8 cancerous lesions, in 60% of the 20 GB specimens and lesions, and including 8 cancerous lesions, in 65% of the 20 BD specimens. K-ras mutations and MSI were detected in 33.3% and 0%, respectively, of 9 hyperplastic lesions, 28.6% and 85.7%, respectively, of 7 dysplastic lesions, and 60.0% and 80.0%, respectively, of 25...Continue Reading

Citations

May 27, 2008·Langenbeck's Archives of Surgery·Takahiko FunabikiShin Ishihara
Oct 7, 2008·Journal of Hepato-biliary-pancreatic Surgery·Hiroyuki NakamuraMichiaki Unno
Dec 26, 2006·Annals of Surgical Oncology·Kjetil Søreide, Jon Arne Søreide
Nov 19, 2004·The British Journal of Surgery·K SöreideJ A Söreide
Nov 11, 2008·The Surgical Clinics of North America·Marc Mesleh, Daniel J Deziel
Apr 13, 2013·Journal of Hepato-biliary-pancreatic Sciences·Yuji MorineHiroshi Shimada
Jun 5, 2014·Journal of Hepato-biliary-pancreatic Sciences·Kosei MaemuraSonshin Takao
Jun 21, 2005·Experimental and Molecular Pathology·Angelica A SaettaEfstratios Patsouris
Feb 15, 2015·Virchows Archiv : an International Journal of Pathology·Andrea P MoyVikram Deshpande
Oct 6, 2016·Journal of Gastroenterology·Terumi KamisawaMasataka Kikuyama
May 20, 2011·Journal of Pediatric Gastroenterology and Nutrition·Kenitiro KanekoHisami Ando
May 26, 2006·Journal of Surgical Oncology·Angelica A Saetta
Nov 20, 2016·Virchows Archiv : an International Journal of Pathology·Hiroshi YoshidaNobuyoshi Hiraoka
Aug 11, 2021·Diagnostic Pathology·Yasuhiro KuraishiTakeji Umemura
Aug 27, 2021·World Journal of Clinical Cases·Xin WuXiao-Dong He

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