Clinical and genetic factors associated with lipoprotein-associated phospholipase A2 in the Framingham Heart Study.

Atherosclerosis
Renate SchnabelEmelia J Benjamin

Abstract

To conduct an investigation of clinical and genetic correlates of lipoprotein-associated phospholipase (Lp-PLA(2)) activity and mass in a large community-based cohort. Higher circulating Lp-PLA(2) predicts cardiovascular disease risk, but sources of inter-individual variability are incompletely understood. We conducted stepwise regression of clinical correlates of Lp-PLA(2) in four Framingham Heart Study cohorts (n=8185; mean age 50+/-14 years, 53.8% women, 9.8% ethnic/racial minority cohort). We also conducted heritability and linkage analyses in Offspring and Generation 3 cohorts (n=6945). In Offspring cohort participants we performed association analyses (n=1535 unrelated) with 1943 common tagging SNPs in 233 inflammatory candidate genes. Sixteen clinical variables explained 57% of the variability in Lp-PLA(2) activity; covariates associated with Lp-PLA(2) mass were similar but only explained 27% of the variability. Multivariable-adjusted heritability estimates for Lp-PLA(2) activity and mass were 41% and 25%, respectively. A linkage peak was observed for Lp-PLA(2) activity (chromosome 6, LOD score 2.4). None of the SNPs achieved experiment-wide statistical significance, though 12 had q values <0.50, and hence we expect at l...Continue Reading

References

Oct 22, 2002·Physiological Genomics·Hainsworth Y ShinMary E Gerritsen
Aug 23, 2003·Biostatistics·H K Tang, D Siegmund
Dec 14, 2006·British Journal of Cancer·J-L SuM-L Kuo
Feb 13, 2007·Mayo Clinic Proceedings·Carolina A GarzaFrancisco Lopez-Jimenez
Jun 26, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shao-Yan ZhangToru Nabika
Jul 28, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Vasilios G SaougosAlexandros D Tselepis
Mar 28, 2008·Journal of the American Geriatrics Society·Curt D FurbergBruce M Psaty
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos

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Citations

Aug 6, 2013·Current Atherosclerosis Reports·Catherine Martel, Gwendalyn J Randolph
Jul 1, 2011·BMC Cardiovascular Disorders·Keane K LeeCarlos Iribarren
May 6, 2010·PLoS Genetics·Sunil SuchindranJeanette J McCarthy
Mar 12, 2009·Genetic Epidemiology·Josée DupuisDavid Siegmund
Dec 17, 2009·Progress in Cardiovascular Nursing·Joung Hee Lee, Marguerite M Engler
Feb 17, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A K HindleF Brody

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