Clinical and genetic features of patients with sporadic amyotrophic lateral sclerosis in south-west China

Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Deng-Fu FangHui-Fang Shang

Abstract

The objective of this study was to analyse clinical and genetic features of patients with sporadic ALS in south-west China. All patients diagnosed with adult-onset sporadic ALS were consecutively followed up, and their clinical characteristics were collected. The frequencies of alleles of six SNPs in the FLJ10986 gene and the association between these SNPs and the clinical features of ALS were analysed. One hundred and sixty-one patients were included in the study. The mean age of onset was 50.9+/-11.4 years. The mean diagnostic delay was 16.5+/-14.3 months and the mean disease duration was 30.7+/-23.5 months. Forty patients (24.2%) died during the period of follow-up. Positive correlation between mean delay and disease duration was found, as was negative correlation between onset age, mean delay and disease duration. The frequency of the 'G' variant of the SNP (rs10493256) was significantly higher than that in a control population. There was no significant difference in the frequencies of variant alleles regarding clinical features. In conclusion, SNP (rs10493256) in the FLJ10986 gene appears to increase the risk of developing sporadic ALS in our Chinese population. Our Clinical findings are in line with other studies. No asso...Continue Reading

References

Jun 2, 2001·The New England Journal of Medicine·L P Rowland, N A Shneider
Jul 24, 2002·Neurology·Eric J SorensonAnthony J Windebank
Feb 26, 2003·Neurology·Jessica MandrioliPatrizia Sola
Mar 12, 2003·Neurology·M A del AguilaG van Belle
Feb 13, 2004·Age and Ageing·Raeburn B ForbesUNKNOWN Scottish ALS/MND Register
Jun 15, 2006·Journal of Neurology·Adam CzaplinskiStanley H Appel
Aug 23, 2006·Nature Reviews. Neuroscience·Piera Pasinelli, Robert H Brown
Sep 6, 2006·Neuromuscular Disorders : NMD·L CorradoL Mazzini
Sep 16, 2006·Biochimica Et Biophysica Acta·Claire L Simpson, Ammar Al-Chalabi
Nov 28, 2006·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Jessica MandrioliPatrizia Sola
Jan 11, 2007·Neurology·E BeghiUNKNOWN SLALOM Group
Jan 16, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M ManninoV La Bella
Jun 1, 2007·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Dafang ChenJun Zhang
Jul 4, 2007·Arquivos de neuro-psiquiatria·Lineu Cesar WerneckRosana Herminia Scola
Aug 3, 2007·The New England Journal of Medicine·Travis DunckleyDietrich A Stephan
Dec 7, 2007·Human Molecular Genetics·Simon CroninOrla Hardiman

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Citations

Feb 22, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Z-Y ZouL-Y Cui
Feb 5, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xueping ChenHuifang Shang
Feb 2, 2012·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Zhang-Yu ZouJiming Kong
Nov 3, 2010·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Khean-Jin GohChong-Tin Tan
Jul 4, 2013·Acta Neurologica Scandinavica·M S LiuUNKNOWN Chinese ALS Association
Aug 17, 2010·Neurobiology of Aging·Rui HuangHui-Fang Shang
Feb 23, 2013·Neurobiology of Aging·YongPing ChenHui-Fang Shang
Feb 3, 2018·Journal of Neurology·Angela RosenbohmUNKNOWN ALS Registry Swabia Study Group
Jul 24, 2015·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Qianqian WeiHuifang Shang
Apr 22, 2011·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Rong YangHui-Fang Shang

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