Clinical and Genetic Findings in 28 American Cocker Spaniels with Aural Ceruminous Gland Hyperplasia and Ectasia.

Journal of Comparative Pathology
Mirja KaimioOuti Laitinen-Vapaavuori

Abstract

American Cocker Spaniels (ACSs) develop aural ceruminous gland hyperplasia and ectasia more often than dogs of other breeds. Data on the cause and development of these breed characteristic histopathological changes are lacking. We performed video-otoscopic examinations and dermatological work-up on 28 ACSs, obtained aural biopsies from each dog and assessed the statistical associations between the presence of ceruminous gland hyperplasia and ectasia and disease history, clinical or microbiological findings and underlying cause of otitis externa (OE). Histological lesions of ceruminous gland hyperplasia and ectasia were observed in aural biopsies from 6/13 clinically healthy ears and 13/15 ears with OE from 19/28 examined dogs. Nine of 28 dogs had histologically normal ceruminous glands (odds ratio [OR] 6.2, 95% confidence interval [CI] 1.1-36.6). Bacterial growth in microbiological culture of aural exudate (OR 14.1, 95% CI 2.1-95.3) was associated with ceruminous glandular changes, whereas previous history of OE, cutaneous findings or underlying allergies were not. Pedigree analysis and a genome-wide association study (GWAS) were performed on 18 affected and eight unaffected dogs based on histopathological diagnosis. While the ...Continue Reading

References

Jul 1, 1988·The Veterinary Clinics of North America. Small Animal Practice·J R August
Oct 1, 1986·The Veterinary Quarterly·I van der Gaag
Apr 9, 1994·The Veterinary Record·H P HuangC J Little
Sep 13, 2001·Veterinary Immunology and Immunopathology·A Hillier, C E Griffin
Jun 1, 2002·The Journal of Small Animal Practice·C J Chesney
Oct 9, 2002·Journal of the American Veterinary Medical Association·John C AngusDavid J Schaeffer
Jul 1, 1961·Journal of Comparative Pathology·G FRASER
Dec 13, 2005·Nature·Kerstin Lindblad-TohEric S Lander
Sep 12, 2007·Veterinary Dermatology·Manolis N SaridomichelakisAlexander F Koutinas
Aug 12, 2008·Molecular Biology and Evolution·Fernando CruzMatthew T Webster
Oct 20, 2009·The Veterinary Journal·Lucy AsherLisa M Collins
Feb 25, 2010·Veterinary Dermatology·Hui-Pi HuangPauline E McNeil
May 5, 2011·The Journal of Small Animal Practice·G ZurT Bdolah-Abram
Apr 21, 2012·Veterinary Dermatology·Jeanette Bannoehr, Luca Guardabassi
Jun 19, 2012·Nature Genetics·Xiang Zhou, Matthew Stephens
May 10, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Boya DengHuachuan Zheng
Feb 28, 2015·GigaScience·Christopher C ChangJames J Lee
Jul 18, 2015·Acta Veterinaria Scandinavica·Thomas GrönthalMerja Rantala
Feb 9, 2016·The Journal of Investigative Dermatology·Charles W BradleyElizabeth A Grice
Mar 1, 2017·Acta Veterinaria Scandinavica·Mirja KaimioOuti Laitinen-Vapaavuori
May 27, 2017·The International Journal of Biochemistry & Cell Biology·Elena Ortiz-ZapaterMaddy Parsons

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