Clinical and Genomic Characterization of Low-Prostate-specific Antigen, High-grade Prostate Cancer.

European Urology
Brandon A MahalPaul L Nguyen

Abstract

The consequences of low prostate-specific antigen (PSA) in high-grade (Gleason 8-10) prostate cancer are unknown. To evaluate the clinical implications and genomic features of low-PSA, high-grade disease. This was a retrospective study of clinical data for 494 793 patients from the National Cancer Data Base and 136 113 patients from the Surveillance, Epidemiology, and End Results program with cT1-4N0M0 prostate cancer (median follow-up 48.9 and 25.0 mo, respectively), and genomic data for 4960 patients from the Decipher Genomic Resource Information Database. Data were collected for 2004-2017. Multivariable Fine-Gray and Cox regressions were used to analyze prostate cancer-specific mortality (PCSM) and all-cause mortality, respectively. For Gleason 8-10 disease, using PSA 4.1-10.0ng/ml (n=38 719) as referent, the distribution of PCSM by PSA was U-shaped, with an adjusted hazard ratio (AHR) of 2.70 for PSA ≤2.5ng/ml (n=3862, p<0.001) versus 1.97, 1.36, and 2.56 for PSA of 2.6-4.0 (n=4199), 10.1-20.0 (n=17 372), and >20.0ng/ml (n=16 114), respectively. By contrast, the distribution of PCSM by PSA was linear for Gleason ≤7 (using PSA 4.1-10.0ng/ml as the referent, n=359 898), with an AHR of 0.41 (p=0.13) for PSA ≤2.5ng/ml (n=37 812...Continue Reading

Citations

Nov 13, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Michael J Duffy
Apr 14, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Peter HammarstenAnders Bergh
Aug 8, 2019·Nature Reviews. Clinical Oncology·James BrierleyMary Gospodarowicz
Apr 6, 2018·International Cancer Conference Journal·Kazutaka KidaNoriyuki Ito
Oct 1, 2019·Therapeutic Advances in Medical Oncology·Ramin AlipourMichael S Hofman
Aug 10, 2019·Molecular Cancer Research : MCR·Peder R BraadlandKristin Austlid Taskén
Feb 12, 2021·Prostate Cancer and Prostatic Diseases·Jacob E BerchuckAna Aparicio
Dec 23, 2020·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·F RozetA Méjean
Dec 24, 2020·Urologic Oncology·Muhammad Umar AlamK C Balaji
Aug 7, 2021·Journal of Personalized Medicine·James MeehanArran K Turnbull
Aug 30, 2021·Translational Oncology·Francesco PellegrinoIlaria Cavarretta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.