Clinical and hematologic benefits of partial splenectomy for congenital hemolytic anemias in children

Annals of Surgery
Henry E RiceRussell E Ware


To assess the role of partial splenectomy for symptomatic children with various congenital hemolytic anemias. The use of total splenectomy for symptomatic children with congenital hemolytic anemias is restricted by concern of postsplenectomy sepsis. A partial splenectomy is an alternative procedure, although its utility remains incompletely defined. This longitudinal cohort study followed 25 symptomatic children with various congenital anemias who underwent partial splenectomy. Sixteen children had hereditary spherocytosis (HS), and nine children had other erythrocyte disorders. Outcome measures were clinical and laboratory hemolysis, splenic phagocytic and immune function, and splenic regrowth as measured by ultrasonography. Discrete parameters were compared using the Student test. Partial splenectomy was successful in all 25 children, with minimal morbidity. Follow-up ranged from 7 months to 6 years (mean 2.3 +/- 1.5 years). Following surgery, children with HS had increased hemoglobin values, decreased reticulocyte and bilirubin levels, and preserved splenic function. Most children without HS had decreased symptoms of hypersplenism and splenic sequestration. Over time, variable rates of splenic regrowth were noted, although r...Continue Reading


Dec 1, 1978·Journal of Pediatric Surgery·J F GoldthornJ A Winkelstein
Jan 1, 1990·Annals of Surgery·P C GuzzettaN Barton
Apr 1, 1988·American Journal of Hematology·W H Reinhart, S Chien
Jul 1, 1985·Seminars in Nuclear Medicine·J R Sty, J J Conway
Mar 1, 1985·Archives of Surgery·M A MalangoniU A Almagro
Jan 1, 1984·American Journal of Diseases of Children·A KorenE Katzuni
Jul 1, 1980·World Journal of Surgery·A S LeonardW Krivit
Jun 1, 1995·Critical Reviews in Oncology/hematology·J Delaunay
Sep 26, 1996·The New England Journal of Medicine·D R GoldD W Dockery
Nov 7, 1996·The New England Journal of Medicine·H S Gold, R C Moellering
Dec 1, 1996·Infectious Disease Clinics of North America·A M Lynch, R Kapila
Mar 1, 1997·Current Opinion in Hematology·Gil TcherniaFrédéric Gauthier
Apr 1, 1997·Journal of Pediatric Surgery·C SandovalS Jayabose
Jul 1, 1997·The Journal of Pediatrics·R A FarahG R Buchanan
Mar 19, 1999·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·I De OdoricoT R Nelson
Oct 29, 1998·Blood Cells, Molecules & Diseases·E FreudM Zer
May 13, 1999·Critical Care Medicine·M L Brigden, A L Pattullo


Oct 7, 2006·Surgical Endoscopy·Sanjeev DuttaJacob C Langer
May 25, 2007·Surgical Endoscopy·C VasilescuC Arion
Aug 24, 2004·Archives of Disease in Childhood·P H B Bolton-Maggs
Sep 23, 2003·AJR. American Journal of Roentgenology·Fumio KimuraMasaru Miyazaki
Jan 1, 2009·Mediterranean Journal of Hematology and Infectious Diseases·Bianca Maria RicercaDeborah Rund
Jan 26, 2013·Mediterranean Journal of Hematology and Infectious Diseases·Mohamed Bejaoui, Naouel Guirat
Oct 11, 2012·Revista brasileira de hematologia e hemoterapia·Maria Christina Lopes Araujo OliveiraMarcos Borato Viana
May 15, 2013·Blood Reviews·Lydie Da CostaNarla Mohandas
Nov 19, 2013·Pediatric Clinics of North America·Patrick G Gallagher
Oct 1, 2013·Surgery·Aaron D SeimsFrederick J Rescorla
Nov 5, 2011·The Journal of Pediatrics·Henry E RiceSplenectomy in Congenital Hemolytic Anemia Consortium
Nov 29, 2015·Journal of Pediatric Surgery·Brian R EnglumSplenectomy in Congenital Hemolytic Anemia Consortium
Jan 18, 2011·Journal of Pediatric Surgery·Keely L BuesingKeith T Oldham
Aug 18, 2010·Journal of Pediatric Surgery·Bethany J SlaterSanjeev Dutta
Oct 23, 2008·Lancet·Silverio PerrottaNarla Mohandas
Jun 20, 2015·American Journal of Hematology·Rachael F GraceBertil Glader
Sep 10, 2008·Journal of Pediatric Surgery·Julia MorinisJacob C Langer
Oct 29, 2008·Advances in Surgery·Frederick J Rescorla, Brian J Duffy
Mar 25, 2008·Journal of Pediatric Surgery·Diana L DiesenHenry E Rice
Apr 22, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Sebastian G de la FuenteHenry E Rice
Nov 8, 2011·British Journal of Haematology·P H B Bolton-MaggsGeneral Haematology Task Force of the British Committee for Standards in Haematology
May 4, 2005·Journal of Pediatric Surgery·Jennifer G HallHenry E Rice
Oct 16, 2014·European Journal of Clinical Investigation·Kaliappan GopalJerald M Kumar
Apr 19, 2017·Pediatric Blood & Cancer·C W K RosmanR Y J Tamminga
Nov 11, 2014·American Journal of Hematology·Henry E RiceSplenectomy in Congenital Hemolytic Anemia (SICHA) Consortium
Sep 14, 2006·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Karim KhelifMarc-Henri De Laet
Nov 24, 2005·Hematology·Patrick G Gallagher
May 13, 2017·Surgical Infections·Brandon DionneThomas R Howdieshell
Aug 4, 2004·British Journal of Haematology·P H B Bolton-MaggsGeneral Haematology Task Force of the British Committee for Standards in Haematology
Jan 21, 2021·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Andrea RomboliRenato Costi
Sep 26, 2007·Annals of Surgery·Frederick J RescorlaJay L Grosfeld
Dec 29, 2004·Annals of Surgery·Gerhard A StoehrStefan W Eber
Jan 21, 2021·Journal of Pediatric Surgery·Niloufar HafeziFrederick J Rescorla

Related Concepts

Anemia, Hemolytic, Congenital
Hematologic Tests
Longitudinal Survey
Natural Regeneration
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