PMID: 11335909May 4, 2001Paper

Clinical and histologic features of level 2 cutaneous malignant melanoma associated with metastasis

Cancer
J M Taran, P J Heenan

Abstract

Metastatic melanoma developing in patients with a level 2 primary cutaneous malignant melanoma (CMM) is rare but has been reported in studies with follow-up periods ranging up to 15 years. The objective of this study was to investigate level 2 CMM associated with metastasis in a population-based retrospective study. In this retrospective population-based study, all level 2 CMMs associated with metastases were identified in Western Australia during 1982-1989 and were followed up to the end of 1996. Pathology reports of 2834 patients were examined. Of these, 1716 had a CMM of maximum tumor thickness 1 mm or less recorded on the pathology report. Of these, 67 had a metastatic melanoma reported on follow-up. Histologic review of these 67 cases under blind conditions identified 5 cases with a level 2 primary CMM followed by metastasis without another primary CMM. All these level 2 CMM showed established regression. Eight other patients were identified with a level 2 CMM, metastatic melanoma, and another primary CMM of at least level 3 invasion. These subsequent primaries occurred before the metastasis had been reported. These findings suggest that metastasis from level 2 CMM without regression is very rare, if it occurs at all.

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Citations

Jan 19, 2007·The New England Journal of Medicine·John F ThompsonArtur Zembowicz
Nov 16, 2007·Annals of Surgical Oncology·Katherine T MorrisMary S Brady
Oct 12, 2010·Dermatology Research and Practice·Bizhan BandarchiGolnar Rasty
Jul 26, 2002·Journal of Cutaneous Pathology·Liana AbramovaJames W Patterson
Aug 27, 2011·Journal of the American Academy of Dermatology·Christopher K BichakjianUNKNOWN American Academy of Dermatology
Nov 22, 2005·Dermatologic Therapy·David E ElderDuPont Guerry
Sep 27, 2003·The British Journal of Dermatology·J OláhA Dobozy
Oct 26, 2016·Melanoma Research·Francesco PiscioliLuca Roncati
Feb 1, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·A Neil CrowsonMartin C Mihm
Apr 13, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David E Elder

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