Clinical and histological evaluation of a single high energy microwave treatment for primary axillary hyperhidrosis in Asians: A prospective, randomized, controlled, split-area comparative trial

Lasers in Surgery and Medicine
Chikako KaminakaYuki Yamamoto

Abstract

Microwave treatment is an effective non-invasive treatment option for primary axillary hyperhidrosis (PAH), but the treatment parameters vary and no histopathological studies have been performed to validate clinical outcomes. This study investigated its efficacy and safety and histopathological changes after a single microwave treatment at the maximum energy level for PAH in Asians. A prospective, clinical, and histological split-area randomized controlled trial (RCT) was performed in Japan. Twenty-six subjects underwent a single microwave treatment at the maximum energy level 5 (5.8 GHz/axilla) on the randomized side of axillae. The primary outcome was the mean difference between both sides in the improvement of modified single-underarm Hyperhidrosis Disease Severity Scale (msHDSS) scores over the course of the 12-month study period from baseline. The secondary outcomes were; the percentage of responders with at least a 2-point drop in the msHDSS score of 3 or 4 group or with a 1-point drop in the msHDSS score of 2 group; the percentage of responders with at least a 75% reduction in sweat weight over 12 months; recurrence rate; and adverse effects. We also performed a histological assessment for 13 selected subjects. Twenty-fo...Continue Reading

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Citations

Mar 17, 2020·Lasers in Surgery and Medicine·Carisa ParrishMalcolm Brock
Nov 19, 2019·Lasers in Surgery and Medicine·Yu-Jia GengYing Shao
Jun 4, 2021·International Journal of Dermatology·Johannes Kjeldstrup Kristensen, Corina Nielsen
Dec 3, 2021·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Si-Qi ChenXiao-Yong Man

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