Clinical and histological features of second breast cancers following radiotherapy for childhood and young adult malignancy

The British Journal of Radiology
C Demoor-GoldschmidtF de Vathaire

Abstract

The purpose of this study was to determine the characteristics of early second breast cancer (SBC) among survivors of childhood and young adult malignancy treated with irradiation. We conducted a multicenter retrospective study of women who presented with breast cancer aged 50 years or younger in nine French centers. 121 patients and 141 SBC were analyzed (invasive = 130; non-invasive = 11). The mean age at first cancer diagnosis was 15 years and at initial SBC diagnosis was 38 years. Bilateral disease before the age of 51 years was diagnosed in 16% of the females. The majority of SBC were invasive carcinomas (92%). Among the invasive carcinomas, 39% had a histoprognostic score of III, 3.1% overexpressed HER2 and 29% were triple negative. The proportion of triple negative phenotype SBC was higher in patients older at first cancer diagnosis [RR = 1.2, 95% CI (1.1-1.3)]. 94% of triple negative SBCs developed in breast tissue which had received >20 Gy. We found a high proportion of aggressive SBC following thoracic radiotherapy in childhood or early adulthood. Advances in knowledge: SBC screening is recommended by scientific societies for these child/young-adulthood cancer survivors in the same way as the one for high risk women b...Continue Reading

References

Nov 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J YahalomP P Rosen
Mar 21, 1996·The New England Journal of Medicine·S BhatiaA T Meadows
Jan 1, 1997·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·B CutuliR Arriagada
Jun 9, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B CutuliR Arriagada
May 23, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·B CutuliM Velten
Jul 11, 2002·Radiation Research·Dale L PrestonJohn D Boice
Jul 3, 2003·Journal of the National Cancer Institute·Flora E van LeeuwenNicola S Russell
Mar 31, 2004·International Journal of Radiation Oncology, Biology, Physics·Jergin ChenDavid K Gaffney
Oct 20, 2004·Annals of Internal Medicine·Lisa B KenneyLisa Diller
Dec 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Catherine GuiboutFlorent de Vathaire
Mar 4, 2006·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Oct 27, 2006·International Journal of Cancer. Journal International Du Cancer·Aliki J TaylorMike M Hawkins
Nov 8, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G SannaA Goldhirsch
Jan 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fabio CastiglioniElda Tagliabue
Aug 30, 2008·International Journal of Radiation Oncology, Biology, Physics·Swati K BasuLouis S Constine
Nov 26, 2008·International Journal of Radiation Oncology, Biology, Physics·Mohamed A Alm El-DinAlphonse G Taghian
Jul 22, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter D InskipJoseph P Neglia
Feb 2, 2010·International Journal of Radiation Oncology, Biology, Physics·Annegien BroeksLaura J Van 't Veer
Mar 5, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Markhaba TukenovaFlorent de Vathaire
Jul 17, 2010·Journal of the National Cancer Institute·Debra L FriedmanJoseph P Neglia
May 18, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elena B ElkinJoachim Yahalom
Feb 22, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C Demoor-GoldschmidtM-A Mahé
May 17, 2012·The Oncologist·Nikolaus Veit-RubinChristine Bouchardy
Jan 3, 2013·International Journal of Cancer. Journal International Du Cancer·Neill PataniMitch Dowsett
Mar 13, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K C HorstR T Hoppe
Jul 11, 2014·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Brigitte LacourJacqueline Clavel
Aug 2, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·David J MulvihillAtif J Khan
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christine Mauz-KörholzDieter Körholz
Aug 2, 2016·The Breast : Official Journal of the European Society of Mastology·Laura SabianiEric Lambaudie
Sep 13, 2016·Nature Communications·Sam BehjatiPeter J Campbell
Apr 1, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K C HorstR T Hoppe

❮ Previous
Next ❯

Citations

Aug 14, 2018·The British Journal of Radiology·Charlotte Demoor-Goldschmidt, Florent de Vathaire
Aug 28, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Candice A M SauderTheresa H M Keegan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer Triple-N

Breast cancer cells have receptors for estrogen, progesterone, HER2 receptors (also called ERBB2). Triple-negative breast cancers do not have any of these receptors. Here are the latest discoveries pertaining to triple-negative breast cancers.

Related Papers

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
C Demoor-GoldschmidtF de Vathaire
The Breast : Official Journal of the European Society of Mastology
Rafael de Deus MouraCarlos E Bacchi
The Pan African Medical Journal
Ghada SahraouiEmna Chelbi
© 2022 Meta ULC. All rights reserved