PMID: 7545352Sep 1, 1995Paper

Clinical and histological features retain their prognostic impact under interferon therapy of CML: a pilot study

American Journal of Hematology
J ThieleR Fischer

Abstract

In 55 patients with Ph1+ CML under interferon (IFN) monotherapy, an immunohistochemical and morphometric study on pretreatment bone marrow biopsies was performed to evaluate the prognostic impact of clinical as well as histological disease features. For identification of megakaryocytes we used the PAS stain and CD61 to calculate the subfraction of precursors (pro- and megakaryoblasts). Demonstration of macrophages and their different subsets was carried out by PG-M1 (CD68) and the GSA-1 lectin. The erythroid precursors were stained by Ret40f (anti-glycophorin C). Density of argyrophilic (reticulin plus collagen) fibers was determined by applying Gomori's silver impregnation method. Clinical variables like state of hematological response to IFN administration, age, spleen and liver size, myeloblasts plus promyelocytes, basophils as well as basophils and eosinophils exerted a predictive capacity by univariate statistical analysis. However, when entering these factors into previously published risk models, i.e., the so-called Sokal score and its modifications, to assess subgroups with different survival patterns or relative risk groups, a clear-cut discrimination was not feasible. Bone marrow features of prognostic value consisted...Continue Reading

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Citations

Feb 1, 1997·Virchows Archiv : an International Journal of Pathology·G BüscheA Georgii
May 6, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J ThieleR Fischer
Mar 16, 2018·Human Fertility : Journal of the British Fertility Society·Rshood KhraifIbrahim Elsegaey
Jun 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H M KvasnickaH E Schaefer

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