Clinical and histopathologic spectrum of alopecia mucinosa/follicular mucinosis and its natural history in children

Journal of the American Academy of Dermatology
Alex ZvulunovMeora Feinmesser

Abstract

Some authorities consider alopecia mucinosa (AM)/follicular mucinosis (FM) to invariably represent mycosis fungoides (MF). This understanding of AM/FM derives from observations in adults. We sought to explore the clinicopathologic features and natural history of pediatric AM/FM. Medical records were searched for children given the diagnosis of AM/FM from 1998 through 2009. Diagnosis of AM/FM was defined as the presence of well-demarcated hairless plaques with follicular prominence plus an abundance of mucin on histopathologic examination. Forty children with a clinical diagnosis of AM/FM were identified. Nine did not meet the inclusion criteria. In the 31 remaining cases (16 boys, 15 girls) the mean age at onset was 9 ± 3.5 years. Histopathologic examination showed folliculotropism in 28 patients (90%) and epidermotropism in 15 (48%). Twelve cases fulfilled the International Society of Cutaneous Lymphomas (ISCL) diagnostic criteria for early MF. The histopathologic findings were typical of MF in only in two of these cases. T-cell receptor gene rearrangement was positive in 3 of 6 (50%) of tested samples, one in a patient who fulfilled the ISCL criteria for early MF. Mean duration of follow-up was 6.2 ± 3.7 years. All skin lesio...Continue Reading

References

Apr 1, 1991·Mayo Clinic Proceedings·D A MehreganS A Muller
Jun 1, 1990·Journal of the American Academy of Dermatology·M S PetersR K Winkelmann
Nov 1, 1988·Pediatric Dermatology·L E GibsonM S Peters
Mar 1, 1985·Pediatric Dermatology·B J Nickoloff, C Wood
Mar 1, 1997·Pediatric Dermatology·P R HickhamR L Fitzgerald
Jul 7, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·M Hess SchmidG Burg
Nov 26, 2002·Journal of Cutaneous Medicine and Surgery·Bryan E AndersonKlaus F Helm
Dec 24, 2003·Acta Dermato-venereologica·Dan Ben-AmitaiEmmilia Hodak
Jan 17, 2004·The American Journal of Dermatopathology·Almut BöerA Bernard Ackerman
Oct 6, 2004·Pediatric Dermatology·Regina Fink-PuchesLorenzo Cerroni
Nov 29, 2005·Journal of the American Academy of Dermatology·Nicola PimpinelliUNKNOWN International Society for Cutaneous Lymphoma
Jul 23, 2008·The British Journal of Dermatology·C MassoneL Cerroni
Dec 5, 2008·Indian Journal of Dermatology, Venereology and Leprology·Y K Inchara, T Rajalakshmi
Jun 27, 2009·Cancer Causes & Control : CCC·Theresa H M KeeganSally L Glaser

❮ Previous
Next ❯

Citations

Dec 12, 2013·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·M Martin PeyraM Fernandez Figueras
Nov 22, 2013·The American Journal of Dermatopathology·Cristina N Brau-JavierJorge L Sánchez
Mar 19, 2014·Journal of the American Academy of Dermatology·Emmilia HodakDan Ben-Amitai
Nov 19, 2013·Journal of the American Academy of Dermatology·Lawrence E Gibson, Dawn M Davis
Nov 19, 2013·Journal of the American Academy of Dermatology·Alex Zvulunov
Mar 19, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·H-R MoonK C Moon
Feb 27, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·W KempfK Kerl
Aug 28, 2015·Anais Brasileiros De Dermatologia·Danielle Cristine WestphalMônica Santos
Apr 29, 2014·Anais Brasileiros De Dermatologia·Paola C Vieira da Rosa PassosLuis Eduardo A Machado Martins
Jun 22, 2018·The American Journal of Dermatopathology·Pinar Incel UysalBasak Yalcin
Jul 5, 2013·The American Journal of Dermatopathology·Denisa KacerovskaDmitry V Kazakov
Jul 25, 2019·Archives of Pathology & Laboratory Medicine·Alejandro A GruAndrea L Salavaggione
Apr 13, 2019·The British Journal of Dermatology·F Rongioletti
Nov 10, 2020·International Journal of Dermatology·Marta Valdivielso-RamosPablo de la Cueva
Feb 4, 2021·JAMA Dermatology·Carolina Carvajal-ZuñigaEduardo Rozas-Muñoz
Feb 26, 2021·Pediatric Dermatology·Ruben González-CuevasPablo Vargas-Mora
Sep 4, 2020·International Journal of Dermatology·Joanna KhalilOssama Abbas
Jun 1, 2021·Dermatologic Clinics·Maria Hordinsky
Mar 27, 2021·Indian Dermatology Online Journal·Mariana EstevesAlberto Mota

❮ Previous
Next ❯

Related Concepts

Related Feeds

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.