PMID: 12771390May 29, 2003Paper

Clinical and histopathological changes of the nasal mucosa induced by occupational exposure to sulphuric acid mists

Occupational and Environmental Medicine
S S GraselE de Oliveira

Abstract

To assess potential alterations of the nasal mucosa by clinical and histopathological evaluation of workers exposed to sulphuric acid mists at anodising plants, correlating the findings with duration of exposure and sulphuric acid concentrations in the air, and comparing them with a control group. Fifty two workers from five plants underwent a clinical evaluation (standard questionnaire, clinical, and ear, nose, and throat examination including nasal endoscopy). For the histopathological study, 20 of the 52 subjects (study group) were randomly selected, as well as 11 unexposed subjects (control group), matched by sex, age, and smoking habits. Nasal biopsy specimens were obtained from the anterior septum mucosa and the anterior curvature of the middle turbinate in each individual. A total of 56 nasal mucosa specimens (37 in the study group and 19 in the control group) were evaluated with regard to normal respiratory epithelium or metaplastic epithelium, atypia or dysplasia, and alterations of the lamina propria. The histopathological study revealed squamous metaplasia in 29 (79%) and atypia in 13 (35%) of the 37 study group samples. No association was found between exposure duration and the clinical and histopathological variabl...Continue Reading

References

Aug 1, 1992·Scandinavian Journal of Work, Environment & Health·C L SoskolneA B Miller
Nov 1, 1988·British Journal of Industrial Medicine·K SteenlandT Bloom
Jan 1, 1988·American Journal of Industrial Medicine·B I Castleman, G E Ziem

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Citations

Aug 27, 2004·Journal of the American Veterinary Medical Association·Lynelle R JohnsonHilde E V De Cock
May 11, 2013·Lung India : Official Organ of Indian Chest Society·Subhashis SahuSubhabrata Moitra
Dec 26, 2006·American Journal of Industrial Medicine·Roberto CastanoDenyse Gautrin

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