Clinical and histopathological effects of heart failure drug therapy in advanced heart failure patients on chronic mechanical circulatory support

European Journal of Heart Failure
Anna CatinoStavros G Drakos

Abstract

Adjuvant heart failure (HF) drug therapy in patients undergoing chronic mechanical circulatory support (MCS) is often used in conjunction with a continuous-flow left ventricular assist device (LVAD), but its potential impact is not well defined. The objective of the present study was to examine the effects of conventional HF drug therapy on myocardial structure and function, peripheral organ function and the incidence of adverse events in the setting of MCS. Patients with chronic HF requiring LVAD support were prospectively enrolled. Paired myocardial tissue samples were obtained prior to LVAD implantation and at transplantation for histopathology. The Meds group comprised patients treated with neurohormonal blocking therapy (concurrent beta-blocker, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker, and aldosterone antagonist), and the No Meds group comprised patients on none of these. Both the Meds (n = 37) and No Meds (n = 44) groups experienced significant improvements in cardiac structure and function over the 6 months following LVAD implantation. The degree of improvement was greater in the Meds group, including after adjustment for baseline differences. There were no differences between the two groups ...Continue Reading

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Citations

Feb 2, 2018·European Journal of Heart Failure·Marco Metra
Feb 23, 2019·Journal of Palliative Medicine·Haider J WarraichKeith M Swetz
May 21, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Teruhiko ImamuraNir Uriel
Jan 31, 2020·ESC Heart Failure·Daniela TomasoniMarco Metra
Aug 3, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Teruhiko ImamuraNir Uriel
Oct 11, 2020·European Journal of Heart Failure·Astrid KassnerHendrik Milting
Dec 6, 2020·ESC Heart Failure·Daniela TomasoniMarco Metra
Jan 20, 2021·Circulation. Heart Failure·Jane E Wilcox, James C Fang
May 14, 2021·Circulation Research·Daniel BurkhoffNir Uriel
Jun 23, 2021·Journal of Cardiac Failure·Jessica Kristin SchnettlerFelix Schoenrath

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