PMID: 15237123Jul 9, 2004Paper

Clinical and immunohistochemical characteristics of benign giant cell tumour of bone with pulmonary metastases: case series

Journal of Orthopaedic Surgery
S OsakaK Suzuki

Abstract

Giant cell tumour of bone with pulmonary metastases is rare. However, some patients die of pulmonary metastases, and histological examination cannot distinguish between benign tumour and malignant metastases. In this study, we present clinical and immunohistochemical findings associated with giant cell tumour of bone with pulmonary metastases. Five patients with benign giant cell tumour of bone with pulmonary metastases (one man and 4 women) were studied. Patients' ages ranged between 20 and 23 years (mean age, 21.8 years). Tumours were in the distal femur in 2 cases, and in the proximal tibia, distal tibia, and lumbar spine in one case each. The tissue specimens from primary tumours, recurrent tumours, and pulmonary metastases were studied using immunohistochemical techniques. Three of the 5 primary tumours were of the spontaneous regression or growth cessation type, or the continuously slow-growing type, showing 4.2% to 6.2% of positive cells for Ki-67 after immunohistochemical staining. However, 2 patients with the rapid-growing type of disease died of pulmonary metastases; their primary, recurrent, and metastatic tumour specimens contained 9.0% to 11.5% of positive cells for Ki-67. Three of the 5 primary tumours had a benig...Continue Reading

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Citations

Dec 17, 2009·Virchows Archiv : an International Journal of Pathology·M AlberghiniN A Athanasou
May 1, 2012·Virchows Archiv : an International Journal of Pathology·F HemingwayN A Athanasou
Dec 12, 2012·CytoJournal·Rajni YadavPrashant Durgapal
Mar 17, 2018·Neurologia i neurochirurgia polska·Kyriakos ParaskevaMarios S Themistocleous
May 15, 2007·Diagnostic Cytopathology·Guoping CaiPascale Levine
Apr 1, 2014·Orthopedics·Derek F AmanatullahRobert M Tamurian
Jun 15, 2021·Pathology International·Eiichi KonishiYasuaki Nakashima
Dec 14, 2011·The American Journal of the Medical Sciences·Jin Chang MoonMyung Ja Chung

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