Clinical and immunologic changes after allergen immunotherapy with Hop Japanese pollen

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
H S ParkK S Jung

Abstract

Hop Japanese (Hop J) pollen has been reported as one of the major causative pollen allergens in the autumn season. There have been no published data regarding the clinical and immunologic effects of Hop J pollen immunotherapy in sensitized patients. In this study, we evaluated clinical and immunologic effects of Hop J immunotherapy. Pollens were collected in our area, and "Depo-Hop J" was prepared in the laboratory of Allergopharma (Reinbek, Germany). Fifteen asthmatic patients who had Hop J immunotherapy for > 1 year were enrolled. Their clinical parameters, such as asthma symptom scores, were monitored. Skin reactivity to Hop J and degree of airway hyperresponsiveness to methacholine were measured before and 1 year after the immunotherapy. Sera were collected before the immunotherapy, at the end of initial therapy, and 1 year after the therapy. Serum total IgE levels were compared by radioimmunoassay. Serum-specific IgE, IgG1, and IgG4 levels to Hop J were compared by ELISA. To evaluate the changes of cellular mechanisms, soluble CD30 (sCD30), soluble interleukin (IL)-2 receptor (sIL-2R), soluble CD23 (sCD23), and IL-10 levels were measured by ELISA. Specific IgG1 and IgG4 levels began to increase at the end of the initial th...Continue Reading

References

Jan 1, 1993·Allergy
Sep 1, 1993·The American Review of Respiratory Disease·T A Platts-Mills
Sep 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Y OhashiM Hayashi
Sep 26, 1997·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Y OhashiM Hayashi
Oct 24, 1997·The Journal of Allergy and Clinical Immunology·H S ParkK Park
Jun 24, 1998·Allergy·M L Kowalski, M Jutel
Sep 2, 1998·The Journal of Allergy and Clinical Immunology·S R Durham, S J Till
Oct 2, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G Mavroleon
Nov 5, 1998·The Journal of Allergy and Clinical Immunology·J BousquetH J Malling
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·U LatzaH Stein

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Citations

Oct 18, 2006·Journal of Korean Medical Science·Young-Min YeHae-Sim Park
Sep 5, 2013·Allergy, Asthma & Immunology Research·Hyun Jung JinHae-Sim Park
Aug 6, 2010·The Cochrane Database of Systematic Reviews·Michael J AbramsonJohn M Weiner

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