PMID: 8947341Nov 1, 1996Paper

Clinical and immunologic evaluation of workers exposed to glutaraldehyde

Allergy
A D CurranK Wiley

Abstract

We describe immunologic responses in subjects exposed to glutaraldehyde (GA) who were diagnosed as having occupational asthma, or who described work-related respiratory symptoms. A series of GA-modified proteins was characterized, and used to analyse sera from 20 GA-exposed workers and 21 unexposed workers for IgE antibodies. Inhibition studies were used to determine the specificity of binding. The reaction of GA with albumin in different molar ratios produced a range of modified proteins, which were used to measure specific IgE antibodies. A significant difference between exposed and unexposed subjects with serum IgE less than 150 kU/l could be detected for GA-specific IgE antibodies (P - 0.026), and 31% of exposed workers with occupational asthma had antibody levels greater than the unexposed population (mean +2.5 SD). False-positive results were obtained with serum from unexposed workers who had total IgE levels greater than 150 kU/l, but this binding was not inhibited by GA-modified proteins. We report the first evidence of immunologic sensitization in some workers exposed to GA. However, GA may behave like many other low-molecular-weight chemicals in that specific antibodies can be detected in only a small percentage of ex...Continue Reading

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Citations

Jan 1, 2006·Environmental Health and Preventive Medicine·Derek R Smith, Rui-Sheng Wang
Jan 30, 2010·Archives of Toxicology·Toru MorinagaToshio Nishikawa
May 30, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Anthony J Frew
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Sep 28, 2012·Journal of Occupational Medicine and Toxicology·Xaver BaurHenning Vellguth
Oct 26, 2006·Sangyō eiseigaku zasshi = Journal of occupational health·Keiko MiyajimaShinji Kumagai
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R J DearmanI Kimber
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Aug 19, 2017·Sangyō eiseigaku zasshi = Journal of occupational health·Shinji Kumagai, Hiroaki Watanabe

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