Aug 22, 2008

Clinical and immunologic features of pediatric patients with common variable immunodeficiency and respiratory complications

Journal of Investigational Allergology & Clinical Immunology
M AydoganI B Barlan


Common variable immunodeficiency (CVID) is the term used to describe a heterogeneous group of B-cell deficiency syndromes characterized by hypogammaglobulinemia, impaired antibody production, and recurrent bacterial infections. To determine the clinical manifestations and perform an immunological analysis of pediatric CVID patients suffering from respiratory complications. The records of 10 patients with CVID who were followed up from 1992 to 2005 (6 males and 4 females) with a median (interquartile range) age of 13.9 (10.4-19.4) years were reviewed. All patients met the standard criteria set for CVID. Median total serum levels of immunoglobulin (Ig) G, IgM, and IgA in mg/dL were 383.5 (239.2-574.5), 32.5 (17.0-117.0), and 12.5 (5.0-30.7), respectively. Median age at the onset of symptoms, at CVID diagnosis, and on starting intravenous Ig therapy was 4.0 (0.8-6.2), 9.4 (6.7-11.3), and 9.1 (7.0-11.6) years, respectively. Associated disorders were recurrent infections (100%), bronchiectasis (90%), and growth failure (80%), whereas malabsorption, malignant neoplasm, inflammatory bowel disease, and autoimmune disorders were less common. All bronchiectatic patients had a low percentage of B cells, with an average of 4% (range, 1%-7%...Continue Reading

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Mentioned in this Paper

Respiratory Complication
Immunoglobulin Activity
Respiratory Tract Diseases
Associative Aphasia
X-Ray Computed Tomography
Failure to Thrive
Antibody Formation

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