Jul 20, 2010

Clinical and immunological analysis of 23 adult patients with common variable immunodeficiency

Journal of Investigational Allergology & Clinical Immunology
O ArdenizA Sin

Abstract

Common variable immunodeficiency (CVID) is characterized by hypogammaglobulinemia, defective antibody production, and recurrent upper and lower airway tract infections. To reveal the clinical heterogeneity of this condition, analyze the high frequency of respiratory and gastrointestinal complications despite satisfactory trough immunoglobulin (Ig) G levels, and determine the main difficulties in management and treatment. We performed a retrospective analysis of 23 patients (13 male and 10 female) diagnosed with CVID between 2001 and 2008. The median diagnostic delay for females and males was 15 years (range, 1-32 years) and 8 years (range, 1-31 years), respectively. Restrictive, obstructive, and combined pulmonary function defects were determined in 23%, 27%, and 14% of patients, respectively. The most frequent findings on the thoracic computed tomography scan were bronchiectasis, mediastinal lymphadenopathy, fibrosis, ground-glass patterns, mosaic oligemia, peribronchial cuffing, and parenchymal nodules. Giardiasis and duodenal lymphoid hyperplasia were detected in 52% and 42% of the patients, respectively, and Helicobacter pylori in 42%. Vitamin A levels were normal, although beta-carotene and/or vitamin E levels were decreas...Continue Reading

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Mentioned in this Paper

Vitamin A
Pathogenic Aspects
Pathogenesis
Cholera Infantum
Nodule
Immunoglobulin Activity
Respiratory Tract Diseases
Peripheral Blood
Antibiotic throat preparations
Helicobacter pylori

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