Clinical and inflammatory features of asthma with dissociation between fractional exhaled nitric oxide and eosinophils in induced sputum

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Astrid CrespoVicente Plaza

Abstract

Measurement of the fractional exhaled nitric oxide (FeNO) and eosinophils in induced sputum are noninvasive markers for assessing airway inflammation in asthma. The clinical usefulness of the correlation between raised FeNO and sputum eosinophilia is controversial. We aimed to examine dissociation between FeNO and sputum eosinophils in a clinical series of asthma patients and to determine whether dissociation between these noninvasive markers was associated with clinical and inflammatory differences in these patients. A total of 110 patients with asthma were included in a cross-sectional study. All of them were on maintenance treatment for asthma. All patients underwent the following on the same day: FeNO, induced sputum, spirometry, serum total IgE levels and skin prick test. The level of asthma control was determined by the Asthma control Test Questionnaire. In 46 (41.8%) patients, a discrepancy between FeNO and sputum eosinophil count was observed, of those, 34 (73.9%) had a FeNO <50 ppb and high eosinophil count, and were characterized by having a predominance of nonallergic asthma with bronchial eosinophilic inflammatory phenotype. Also, 12 (26.1%) patients had FeNO ≥50 ppb and sputum eosinophilia within the normal referen...Continue Reading

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Citations

Sep 15, 2016·Expert Review of Respiratory Medicine·Hanneke Coumou, Elisabeth H Bel
Nov 9, 2017·Nutrients·Laurent GuilleminaultLisa G Wood
Jun 24, 2017·Journal of Oral Science·Hossam AsaadOmar Kujan
Dec 1, 2018·BioMed Research International·L BrussinoG Rolla
Sep 29, 2020·Journal of Asthma and Allergy·Francesco MenzellaNicola Facciolongo
Sep 25, 2019·Expert Review of Clinical Immunology·Marco CaminatiLanny J Rosenwasser
Dec 15, 2020·Allergy·Astrid Crespo-LessmannUNKNOWN Consensus Group
Mar 8, 2021·Revue des maladies respiratoires·L Guilleminault
May 5, 2021·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Yi JiangYufeng Guo

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