Clinical and instrumental assessment of the effects of a new product based on hydroxypropyl chitosan and potassium azeloyl diglycinate in the management of rosacea.

Journal of Cosmetic Dermatology
Enzo BerardescaGérald E Piérard

Abstract

  Rosacea is a chronic inflammatory skin disease affecting mostly facial skin. Its origin is multifactorial. Important steps in its treatment are avoidance of any triggering factor and control of skin inflammation.   To assess the benefit of topical applications of a new product (P-3075).   A randomized, multicenter, double-blind, placebo-controlled, parallel-group, pilot study was carried out to evaluate the efficacy and tolerability of a cream (P-3075) based on 5% potassium azeloyl diglycinate (PAD, Azeloglicina(®)) and 1% hydroxypropyl chitosan (HPCH). Forty-two patients (rosacea stages I and II) were enrolled and randomized, 28 in the P-3075 group and 14 in the placebo group. They were asked to apply the cream twice daily for 4 weeks. The main assessments were the objective quantification of erythema and skin hydration using the Mexameter(®) and Corneometer(®) devices, respectively. Clinical signs and symptoms were evaluated on a four-point scale.   The P-3075 cream applied for 28 days was effective in skin protection by reducing erythema, evaluated both instrumentally and clinically. In addition, the clinical assessments of other symptoms such as flushing, stinging, and burning supported the beneficial effect of the P-3075...Continue Reading

References

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Apr 4, 2003·Dermatology : International Journal for Clinical and Investigative Dermatology·Claudine Piérard-FranchimontGérald E Piérard
Sep 1, 2004·Journal of the American Academy of Dermatology·Glen H CrawfordWilliam D James
Feb 12, 2005·Drug Development and Industrial Pharmacy·Daniela MontiF Mailland
Feb 8, 2008·Journal of Cosmetic Dermatology·Enzo BerardescaGianfranco de Paoli Ambrosi
Jun 2, 2009·Journal of Dermatological Science·Kenshi Yamasaki, Richard L Gallo

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Citations

Jun 24, 2015·The British Journal of Dermatology·E J van Zuuren, Z Fedorowicz
Mar 24, 2015·Journal of the American Academy of Dermatology·Dennis HopkinsonSteven R Feldman
May 24, 2019·The British Journal of Dermatology·J G M LoggerR J B Driessen
Apr 29, 2015·The Cochrane Database of Systematic Reviews·Esther J van ZuurenLyn Charland
May 6, 2020·Clinical, Cosmetic and Investigational Dermatology·Daniele MaggioniClaudio Angelinetta
Jan 5, 2022·Journal of Cosmetic Dermatology·Shasha ZhaoYan Yan

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