Clinical and Kinematic Features of Valproate-Induced Tremor and Differences with Essential Tremor.

The Cerebellum
Giulia PaparellaMatteo Bologna

Abstract

Tremor is a common movement disorder that can be induced by medications, including valproate, which is used for the treatment of epilepsy. However, the clinical and neurophysiological features of valproate-induced tremor are still under-investigated. We performed a clinical and kinematic assessment of valproate-induced tremor by considering tremor body distribution and activation conditions. We investigated possible correlations between demographic and clinical data and kinematic features. Valproate-induced tremor results were also compared with those collected in a large sample of patients with essential tremor. Sixteen valproate-induced tremor patients and 93 essential tremor patients were enrolled. All participants underwent a standardised neurological examination and video recording. Patients also underwent an objective assessment of postural, kinetic and rest tremor of the upper limbs and head tremor through kinematic analysis. Nonparametric tests were used for statistical comparisons between the two groups. Clinical evaluation showed a higher occurrence of rest tremor as well as head or voice, and lower limb involvement in patients with valproate-induced tremor. Kinematic analysis showed a substantial variability in the t...Continue Reading

References

Aug 1, 1979·Neurology·N M HymanK G Sinclair
Feb 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·M HallettC D Marsden
Apr 1, 1982·Neurology·B J KarasA W Bauman
Oct 1, 1995·Annals of Neurology·O PapazianJ Aicardi
Nov 22, 2005·Lancet Neurology·John C Morgan, Kapil D Sethi
Oct 3, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·C ZadikoffA Lang
Sep 5, 2008·Neurological Research·Eniko VamosPeter Klivenyi
Jan 5, 2011·The Cerebellum·Timothy J EbnerLaurentiu S Popa
Jan 19, 2011·Indian Journal of Pediatrics·Vidya B GhoshSinchana Bhatt
Mar 10, 2011·Annals of Neurology·Rick C HelmichIvan Toni
Jun 10, 2011·The Cerebellum·Elan D LouisJean-Paul G Vonsattel
Dec 23, 2011·Parkinsonism & Related Disorders·Mark Hallett
May 10, 2013·Current Drug Safety·Antonio SiniscalchiGiovambattista De Sarro
Jul 31, 2013·Current Neurology and Neuroscience Reports·Rick C HelmichBastiaan R Bloem
Dec 17, 2016·Neuroscience·Stacey L Main, Randy J Kulesza
Jul 7, 2017·Cerebellum & Ataxias·Jonathan P DykeElan D Louis
Sep 25, 2017·Parkinsonism & Related Disorders·Marlene Alonso-JuarezJosé Fidel Baizabal-Carvallo
Dec 2, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Kailash P BhatiaUNKNOWN Tremor Task Force of the International Parkinson and Movement Disorder Society
Dec 6, 2017·Tremor and Other Hyperkinetic Movements·John C MorganKapil D Sethi
May 12, 2018·Acta Neurologica Scandinavica·M Alonso-Juarez, J F Baizabal-Carvallo
Aug 20, 2019·The Cerebellum·Matteo BolognaAlfredo Berardelli
Sep 12, 2019·Brain : a Journal of Neurology·Michiel F DirkxRick C Helmich
Nov 14, 2019·Acta neurologica Belgica·José Fidel Baizabal-Carvallo, Marlene Alonso-Juarez
Dec 14, 2019·Brain : a Journal of Neurology·Matteo BolognaAlfredo Berardelli
May 13, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M BolognaA Berardelli

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Citations

Aug 16, 2021·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Anna LoussouarnCyril Mignot

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