PMID: 8604172Jan 17, 1996Paper

Clinical and laboratory characteristics of human granulocytic ehrlichiosis

JAMA : the Journal of the American Medical Association
J S BakkenJ S Dumler

Abstract

To characterize the clinical and laboratory features observed in patients with human granulocytic ehrlichiosis (HGE) and evaluate the utility of the diagnostic tools used to confirm the diagnosis. Retrospective case study of 41 patients with laboratory-diagnosed HGE. A total of 228 patients from Minnesota and Wisconsin were evaluated between June 1990 and May 1995. Cases were presumptively identified by a history of an influenzalike illness acquired in an area known to be endemic for ticks. Diagnostic laboratory testing included microscopic examination of Wright-stained peripheral blood smears for presence of neutrophilic morulae, polymerase chain reaction (PCR) analysis of acute-phase blood samples for the Ehrlichia phagocytophila/Ehrlichia equi group DNA, and evaluation of serological responses by indirect immunofluorescent antibody assay (IFA), using E equi as antigen. All patients presented with a temperature of at least 37.6 degrees C, and most had headache, myalgias, chills, and varying combinations of leukopenia, anemia, and thrombocytopenia. Eighty percent of the patients tested demonstrated morulae in the cytoplasm of peripheral blood neutrophils. Only 16 of 37 patients tested by PCR were positive for HGE, whereas seru...Continue Reading

Citations

Apr 16, 2014·Western Pacific Surveillance and Response Journal : WPSAR·UNKNOWN Javkhlan GUNKNOWN Battsetseg B
Mar 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J S BakkenJ S Dumler
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