Clinical and laboratory diagnosis of respiratory syncytial virus infection

Critical Reviews in Clinical Laboratory Sciences
R C WelliverPearay L Ogra

Abstract

Infection with RSV is one of the most common respiratory viral infections in childhood, particularly in infants under 1 year of age. The disease is characterized by epidemic proportions of infection which occur regularly in all parts of the world in the winter months. The spectrum of the clinical disease is quite variable, and the infection may present as bronchiolitis, pneumonia, croup, or exacerbation of pre-existing reactive airway disease. Recent evidence has suggested that RSV infection may be frequently associated with apnea in infancy and possibly sudden-infant-death syndrome. Although the laboratory diagnosis of this infection can be successfully accomplished by any well-known and conventional procedures, such as tissue culture infectivity and determination of serologic response, recently it has become possible to diagnose the infection very rapidly by application of such techiques as immunofluorescent staining and enzyme-linked immunonoabsorbent assay (ELISA).

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Citations

Jun 12, 1998·Tropical Medicine & International Health : TM & IH·M W WeberB M Greenwood
Apr 3, 2003·The Pediatric Infectious Disease Journal·Lone Graff StensballeEric A Simoes
May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R A TrippM P Brown

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