PMID: 6163391Nov 1, 1980Paper

Clinical and laboratory evaluation of four methods of assessing free thyroxine status in thyroid clinic patients

Annals of Clinical Biochemistry
J A FyffeJ G Ratcliffe

Abstract

The clinical value of four laboratory methods of assessing free thyroxine status was compared in 82 consecutive patients newly referred to a thyroid clinic with suspected thyroid dysfunction. The methods of determining free thyroxine used were: (1) free thyroxine index using a thyroid hormone uptake test (FTI (THUT)); (2) a free thyroxine index using thyroxine binding globulin (FTI (TBG)); (3) a kinetic radioimmunoassay (Immophase); and (4) an equilibrium dialysis method. The definitive thyroid status was evaluated by a combination of clinical assessment (including Wayne index), routine tests of thyroid function (total T4, T3, TSH, and TRH tests where appropriate), and by therapeutic trial in one case. The diagnostic efficiency of the tests was markedly dependent upon the method of determining the reference range for euthyroid patients. Best efficiency for each test was achieved using an amended range after excluding outliners. Test efficiency was then 97.6% for FTI (THUT) and the kinetic RIA and 96.8% for FTI (TBG). Misclassification by one or more of these tests occurred in only four patients (mild hypothyroid, euthyroid on phenytoin, euthyroid on oral contraceptive and valium, T3 hyperthyroid). In contrast, free T4 by equili...Continue Reading

References

Nov 1, 1979·Metabolism: Clinical and Experimental·R R CavalieriK Cruse
Apr 2, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·G S ChallandJ G Ratcliffe
Jan 1, 1966·The Journal of Clinical Investigation·K Sterling, M A Brenner
Sep 1, 1974·American Journal of Clinical Pathology·F WilsonJ B Henry
Apr 1, 1974·The Journal of Clinical Endocrinology and Metabolism·C H Irvine
May 30, 1970·British Medical Journal·F Clark, H J Brown
Jan 9, 1960·British Medical Journal·E J WAYNE

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Citations

Jan 1, 1983·Annals of Clinical Biochemistry·T J Wilke
Jan 22, 1983·The Medical Journal of Australia·F WatsonD T Khin

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