Clinical and laboratory evaluation of idiopathic male infertility in a secondary referral center in India.

Journal of Clinical Laboratory Analysis
Shadaan AbidJyotsna Gokral

Abstract

The genetic basis of infertility has received increasing recognition in recent years, particularly with the advent of assisted reproductive technology. It is now becoming obvious that genetic etiology for infertility is an important cause of disrupted spermatogenesis. Y-chromosome microdeletions and abnormal karyotype are the two major causes of altered spermatogenesis. To achieve biological fatherhood, intracytoplasmic sperm injection (ICSI) is performed in cases of severe infertility with or without genetic abnormalities. There is a concern that these genetic abnormalities can be transmitted to the male progeny, who may subsequently have a more severe phenotype of infertility. A total of 200 men were recruited for clinical examinations, spermiograms, hormonal profiles, and cytogenetic and Yq microdeletion profiles. Testicular biopsy was also performed whenever possible and histologically evaluated. Genetic abnormalities were seen in 7.1% of cases, of which 4.1% had chromosomal aberrations, namely Klinefelter's mosaic (47XXY) and Robertsonian translocation, and 3.0% had Yq microdeletions, which is very low as compared to other populations. Follicle stimulating hormone (FSH) and luteinizing hormone (LH) were significantly incre...Continue Reading

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Citations

Mar 30, 2012·Journal of Assisted Reproduction and Genetics·Min Jee KimHyoung-Song Lee
Aug 13, 2013·Journal of Assisted Reproduction and Genetics·Sanjukta SenDeepak Modi
Feb 7, 2013·Journal of Biosciences·Shadaan AbidDeepak Modi
Jun 5, 2014·BioMed Research International·Trpimir GolužaDavor Ježek
Sep 14, 2011·Journal of Assisted Reproduction and Genetics·Sean E HofherrDaniel L Van Dyke
Nov 12, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Tania Morielli, Cristian O'Flaherty
Dec 15, 2015·Reproductive Biomedicine Online·Sanjukta SenDeepak Modi
Dec 21, 2012·Fertility and Sterility·Gülşen AktanNecla Koçak-Toker
Aug 7, 2008·Reproductive Biomedicine Online·Shadaan AbidDeepak Modi
Jul 21, 2009·Molecular and Cellular Endocrinology·Kristy M NicksDana Gaddy
Apr 23, 2015·Basic and Clinical Andrology·Shivaprasad Holenarasipura Sathyanarayana, Suttur Srikanta Naik Malini
Apr 19, 2018·Journal of Cellular Physiology·Zahra PourmoghadamMehdi Yousefi
Feb 20, 2018·Reproductive Biology and Endocrinology : RB&E·Stacy Colaco, Deepak Modi
May 7, 2020·The Journal of Clinical Endocrinology and Metabolism·Manuela SimoniLivio Casarini
Oct 22, 2020·Indian Journal of Endocrinology and Metabolism·Jayakumar S AmbigapathyNandhini Lakshmana Perumal

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