Clinical and laboratory evaluation of the treatment of von Willebrand's disease patients with heat-treated factor VIII concentrate (BPL 8Y)

British Journal of Haematology
K J PasiF G Hill

Abstract

Adequate rises of vWF:activity and satisfactory haemostasis have been obtained in six von Willebrand patients treated with heated 8Y factor VIII concentrate, despite multimeric analysis showing the concentrate to have an alteration in the proportions of the different vWF:Ag multimers including slight loss of the highest molecular weight multimers and an abnormal triplet. As heat-treated concentrates reduce the risk of transmitting blood borne viruses 8Y concentrate should be considered as a possible first line treatment of vWD patients in the U.K. if they do not have mild forms of type I von Willebrand's disease which can be treated with desmopressin (DDAVP) infusions.

References

Dec 1, 1977·British Journal of Haematology·I M Nilsson, U Hedner
Mar 1, 1976·The American Journal of Medicine·D Green, E V Potter
Apr 1, 1976·The Journal of Pediatrics·K J Cullen
Mar 1, 1989·Thrombosis Research·R K SmileyG Rock
Oct 1, 1989·Archives of Disease in Childhood·K J Pasi, F G Hill

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Citations

Feb 13, 2001·British Journal of Haematology·S L AllfordS J Machin
Feb 24, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·J M Lusher
Aug 13, 2004·The New England Journal of Medicine·Pier Mannuccio Mannucci
Mar 1, 1993·Transfusion Medicine·A FarrugiaA Oates
Apr 11, 2001·American Journal of Clinical Pathology·C CescaR S Riley
Dec 3, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·I C Nitu-WhalleyC A Lee
May 16, 2002·Haemophilia : the Official Journal of the World Federation of Hemophilia·J BatlleM F Lopez-Fernandez
Jan 20, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·E BerntorpUNKNOWN European Wilate Study Group
Sep 30, 2009·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Javier BatlleMaría Almudena Pérez-Rodríguez
May 1, 1995·The Journal of Laryngology and Otology·G H AlusiM P Stearns
Jun 28, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·M MatysiakC H Dash
Mar 27, 2001·Blood·P M Mannucci
Apr 17, 2004·Haemophilia : the Official Journal of the World Federation of Hemophilia·K J PasiI R Peake
Oct 17, 2001·American Journal of Clinical Pathology·J D StudtM Barthels
Aug 15, 1998·The American Journal of the Medical Sciences·M D Phillips, A Santhouse
Aug 1, 1993·Critical Reviews in Oncology/hematology·S Lethagen
Apr 1, 1991·Baillière's Clinical Haematology·V S BlanchetteC Turner

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