PMID: 6965862Mar 1, 1980Paper

Clinical and laboratory features of canine lupus syndromes

Arthritis and Rheumatism
J C MonierM Lapras

Abstract

Determination of the specificities of antinuclear antibodies in the sera of 20 dogs presenting with symptoms of a lupus-like syndrome permitted their separation into 2 groups. The first group of 14 dogs all had antibody activity to DNA-histone antigen(s), and 4 of them also had antibodies to native DNA (nDNA). The Farr test with standard buffer was found to be unsatisfactory for the measurement of anti-nDNA antibodies in dog sera due to a high incidence of false positive reactions; these could be eliminated by the inclusion of sodium dodecyl sulfate in the buffer system. The second group of 6 dogs was characterized by the presence of antibodies to extractable nuclear antigen. In every serum tested diseased dogs had a diminished level of circulating thymic factor as compared to controls of the same age, suggesting that a diminution of suppressor T cells may be an etiologic factor.

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Citations

Jan 1, 1984·Archives of Dermatological Research·F FurukawaY Hamashima
Sep 1, 1984·Veterinary Immunology and Immunopathology·J ZeromskiV Stejskal
Oct 1, 1984·Veterinary Immunology and Immunopathology·O CostaM Fontaine
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Jul 1, 1992·Annals of the Rheumatic Diseases·R J Powell, D R Jones
Nov 9, 2015·Veterinary Immunology and Immunopathology·Hanna D BremerHelene Hansson-Hamlin
Nov 10, 2004·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·E ChoiC Lee
Jan 1, 1997·Research in Veterinary Science·S C BellS D Carter
Dec 1, 1982·The Journal of Dermatology·F Furukawa, Y Hamashima
Apr 1, 1985·Clinical Immunology and Immunopathology·M J DayR L Dawkins
Jul 1, 1985·Clinics in Dermatology·K J Shanley
Nov 9, 2005·Microscopy Research and Technique·David M SanderRobert F Garry
Jun 1, 1988·European Journal of Immunology·M ZoualiB D Stollar
Mar 21, 2018·Scientific Reports·Hanna D BremerHelene Hansson-Hamlin
Mar 1, 1984·Tissue Antigens·P H Kay, R L Dawkins
Jan 1, 1995·Clinical and Experimental Immunology·M MonestierD Rigal

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