Clinical and laboratory features of neuropathies with serum IgM binding to TS-HDS

Muscle & Nerve
A PestronkM T Al-Lozi

Abstract

In this investigation we studied clinical and laboratory features of polyneuropathies in patients with serum IgM binding to the trisulfated disaccharide IdoA2S-GlcNS-6S (TS-HDS). We retrospectively compared 58 patients with selective IgM binding to TS-HDS to 41 consecutive patients with polyneuropathies without TS-HDS binding. Patients with IgM vs. TS-HDS commonly had distal, sensory, axonal neuropathies. Weakness was associated with IgM M-proteins. Hand pain and serum IgM M-proteins were more common than in control neuropathy patients. TS-HDS antibody binding was often selectively κ class. Biopsies showed capillary pathology with thickened basal lamina and C5b9 complement deposition. IgM in sera with TS-HDS antibodies often bound to capillaries. Serum IgM binding to TS-HDS is associated with painful, sensory > motor, polyneuropathies with an increased frequency of persistent hand discomfort, serum IgM M-proteins, and capillary pathology. Serum IgM binding to TS-HDS suggests a possible immune etiology underlying some otherwise idiopathic sensory polyneuropathies.

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Citations

Mar 1, 2013·Muscle & Nerve·Georgios ManousakisAlan Pestronk
Aug 24, 2016·Journal of Clinical Neuromuscular Disease·Jafar KafaieErik Krause
Nov 28, 2019·Current Neurology and Neuroscience Reports·Khosro Farhad
Dec 15, 2019·Journal of the Peripheral Nervous System : JPNS·Matteo TagliapietraSalvatore Monaco
Aug 23, 2017·Journal of Clinical Neuromuscular Disease·Jafar KafaieAlan Pestronk
Apr 11, 2018·Journal of Neurology·Rocio Garcia-SantibanezRobert C Bucelli
Oct 22, 2020·The New England Journal of Medicine·Anthony A Amato, Allan H Ropper
Feb 18, 2021·Journal of Clinical Neuromuscular Disease·Melissa K Cook, Morgan Jordan
Nov 24, 2020·Neurologic Clinics·Lawrence A Zeidman
Apr 2, 2021·Muscle & Nerve·Jorge A Trevino, Peter Novak
Aug 11, 2021·Muscle & Nerve·Franco GemignaniGiovanni Pavesi
Nov 9, 2021·Frontiers in Neurology·Christopher M BartleyMichael R Wilson

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