Clinical and laboratory findings and results of therapy in 58 patients with adrenocortical tumors admitted to a single medical center (1951 to 1978)

The American Journal of Medicine
C Bertagna, D N Orth


We reviewed 150 findings in 58 patients (14 males and 44 females) with adrenocortical tumors (26 with adenoma and 32 with carcinoma) admitted to Vanderbilt Hospital during 28 years. In general, our findings agree with those reported by others in multi-institutional series or literature reviews. Adenomas took longer to diagnose than carcinomas. Adenomas usually caused Cushing's syndrome, but two caused virilization and three caused no endocrine syndrome. There was no difference in time required for diagnosis of carcinoma in men or women or in those with Cushing's syndrome, virilization or no endocrine syndrome. Urinary 17-hydroxycorticoid (17-OHCS) levels were similar in those with adenoma and those with carcinoma, but 17-ketosteroid (17-KS) levels were usually less than 20 mg per day in patients with adenoma and greater than 20 mg per day in patients with carcinoma. Adenomas were uniformly independent of endogenous ACTH stimulation, but frequently responded to exogenous ACTH. As with adenomas, no carcinoma demonstrated normal suppression with dexamethasone or normal response to metyrapone, but only one responded to exogenous ACTH. Some patients had no clinical Cushing's syndrome despite high levels of plasma cortisol and urine ...Continue Reading


Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S Lavi, Y Groner
Feb 1, 1975·Cancer·R A HajjarN A Samaan
May 1, 1975·Urology·C K Tang, G F Gray
Nov 1, 1958·Journal of Chronic Diseases·A H SHAMMAS C SOMMERS
Sep 1, 1963·The Journal of Clinical Endocrinology and Metabolism·D K FUKUSHIMA, T F GALLAGHER
Sep 1, 1963·The American Journal of Medicine·M B LIPSETTG T ROSS
Aug 1, 1959·The Journal of Clinical Endocrinology and Metabolism·G W LIDDLEA W TOWNES
Sep 1, 1962·The Journal of Clinical Endocrinology and Metabolism·M B LIPSETT, H WILSON


Aug 8, 1998·International Urology and Nephrology·Y KubotaK Kawai
Jan 1, 1996·International Urology and Nephrology·E D FokaefsG A Barbalias
Mar 23, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M MinettoM Terzolo
Sep 25, 2002·Journal of Internal Medicine·B BülowSwedish Research Council Study Group of Endocrine Abdominal Tumours
Nov 15, 1990·The New England Journal of Medicine·N S Ross, D C Aron
Jan 31, 1991·The New England Journal of Medicine·P CoenR Santen
Oct 13, 1994·The New England Journal of Medicine·J DerksenC J van de Velde
Mar 23, 1995·The New England Journal of Medicine·D N Orth
May 1, 1984·Annals of Surgery·C G ThomasF B Askin
May 1, 1985·Annals of Surgery·H W ScottD N Orth
Nov 1, 1990·The British Journal of Dermatology·R W GrovesD M MacDonald
Jun 1, 1991·Clinical Endocrinology·A B Atkinson
Apr 1, 1994·Clinical Endocrinology·C GicquelY Le Bouc
Apr 1, 1988·Postgraduate Medical Journal·N S PanesarC S Cockram
Jun 1, 1993·Postgraduate Medical Journal·D LaniganJ Evans
Aug 1, 1994·Postgraduate Medical Journal·M PajaJ Estrada
Dec 16, 2004·The Journal of Clinical Endocrinology and Metabolism·M O van AkenF Roelfsema
Jun 1, 1996·Journal of Endocrinological Investigation·E DelgrangeM Lambert
Nov 1, 2001·Journal of Endocrinological Investigation·F A LószióM Szécsi
Sep 13, 2008·Journal of Endocrinological Investigation·S S LeeS K Kang
Mar 17, 2012·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Mohammed MawardiPaul Marotta
Mar 25, 2000·Endocrinology and Metabolism Clinics of North America·D E Schteingart
Mar 1, 1997·Endocrinology and Metabolism Clinics of North America·R M Chidiac, D C Aron
Oct 1, 1996·Disease-a-month : DM·B E AkpunonuE A Hoffman
Feb 24, 1998·The Journal of Emergency Medicine·M Fulop
Aug 1, 1995·Trends in Endocrinology and Metabolism : TEM·H Lavoie, A Lacroix
Feb 2, 1999·American Journal of Surgery·S P BowersS Huerd
Nov 1, 1985·Clinics in Endocrinology and Metabolism·A M Neville, M J O'Hare
Apr 23, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Takahisa SuzukiYutaka Oki
Oct 17, 2014·Annals of Surgical Oncology·Julian C Y IpStan B Sidhu
Jun 4, 2015·Endocrinology and Metabolism Clinics of North America·Gustavo G Fernandez Ranvier, William B Inabnet
Jan 13, 2015·Case Reports in Endocrinology·Murat AtmacaYasin Sezgin
Mar 24, 1998·Clinical Endocrinology·M TerzoloA Angeli
Jun 1, 1988·The Australian and New Zealand Journal of Surgery·A P MeagherM Yeates
Sep 27, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·B C FigueiredoR Sandrini
Jun 1, 1984·The American Journal of Medicine·D J GreathouseF D Hofeldt
Oct 1, 1988·Seminars in Roentgenology·T C Williams
Sep 1, 1995·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·P van ZonneveldT J van Vroonhoven
May 1, 1982·The American Journal of Medicine·R G Wieland
Dec 14, 2004·World Journal of Surgery·Libuse TauchmanovàRiccardo Rossi
Sep 17, 2014·European Journal of Endocrinology·Marios C MarkopoulosGregory Kaltsas
Jul 10, 2018·The Journal of Clinical Endocrinology and Metabolism·Sri Harsha TellaElectron Kebebew
Nov 20, 1997·The Journal of Urology·J A DaitchA C Novick
May 15, 1995·Cancer·A A Kasperlik-ZałuskaA M Makowska
Aug 1, 1987·Cancer·P H Lange, H N Winfield
Oct 11, 2008·Dermatologic Therapy·Najwa SomaniWilma F Bergfeld
Dec 1, 2007·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Marco LodinGiorgio Giannone
Feb 13, 2001·Endocrine Reviews·A LacroixP Hamet
Jun 1, 2014·The Journal of Clinical Endocrinology and Metabolism·Guido Di DalmaziMartin Reincke
Oct 31, 2019·The Journal of Clinical Endocrinology and Metabolism·German RubinsteinMartin Reincke
Jun 1, 1985·Journal of Surgical Oncology·C P KarakousisR Moore
Apr 26, 1990·The New England Journal of Medicine·J P LutonP Blondeau
Mar 23, 2006·The Journal of Clinical Endocrinology and Metabolism·Bruno Allolio, Martin Fassnacht
Dec 21, 2012·Oncology Letters·Baozhong LiJianyun Guan
Jan 1, 1986·Drug Intelligence & Clinical Pharmacy·C A May, W R Garnett
Feb 1, 1989·The Journal of Urology·B BodieP Schumacher
Jan 1, 1992·Medical and Pediatric Oncology·M AricòF Severi
Dec 8, 1998·Pediatric Hematology and Oncology·C P DriverJ Bruce
Oct 30, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Farhad ZangenehFereydoun Zangeneh
Jul 13, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Erika F BrutsaertA C Levine
May 1, 1992·Journal of Endocrinological Investigation·F JockenhövelD Reinwein
Jul 1, 1984·Indian Journal of Pediatrics·S GargR J Dash
Apr 28, 1999·Journal of Surgical Oncology·N B Tütüncü, O Gedik
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ann T SweeneyGeorge L Tully
Sep 23, 2016·International Journal of Endocrinology·Asli Dogruk UnalNeslihan Bascil Tutuncu
Feb 27, 2003·Journal of Endocrinological Investigation·C EremE Sencer
Aug 1, 1982·The Journal of Urology·H GrabstaldP Bukberg
Jun 5, 2015·Journal of Veterinary Science·Donghoon LeeDong-Woo Chang
Jan 1, 1988·Pediatric Hematology and Oncology·C KrzisnikB Jereb

Related Concepts

Adenoma, Trabecular
Adrenal Cortex Function Tests
Malignant Neoplasm of Adrenal Cortex
Cushing Syndrome
Differential Diagnosis
SU 4885

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.