Clinical and laboratory heterogeneity in idiopathic hypogonadotropic hypogonadism

The Journal of Clinical Endocrinology and Metabolism
R M BoyarJ W Finkelstein

Abstract

Six young men with idiopathic hypogonadotropic hypogonadism had 24-h frequent blood sampling studies for measurement of LH, FSH and testosterone. Five of the patients had LH and FSH measured after administration of 100 mug LH-RH during waking and then during sleep. Four of the patients had testicular biopsies performed. The results of the present studies showed that 4 of the patients had no evidence of episodic LH, FSH, or testosterone secretion. The two patients who showed significant sleep related pulses of LH had the highest 24 h mean testosterone concentrations, the best responses to exogenous LH-RH and the most differentiated testicular biopsies. Sleep had no effect on the release of LH or FSH in response to LH-RH. These sutdies suggest that the clinical and laboratory heterogeneity of idiopathic hypogonadotropic hypogonadism may be the result of differences in the degree of endogenous LH-RH deficiency.

Citations

May 1, 1993·The International Journal of Eating Disorders·R E WhiteJ H Lacey
Dec 6, 2003·Molecular and Cellular Endocrinology·Jacques YoungPhilippe Chanson
Jan 29, 1999·Endocrinology and Metabolism Clinics of North America·F J HayesW F Crowley
May 20, 1982·The New England Journal of Medicine·D B Hier, W F Crowley
Oct 14, 1982·The New England Journal of Medicine·D Rodbard, H Wachslight-Rodbard
Jan 22, 2002·Journal of Computer Assisted Tomography·Robert I Henkin, Lucien M Levy
Oct 2, 2013·Indian Journal of Endocrinology and Metabolism·Bindu KulshreshthaAriachery Ammini
Apr 12, 2006·Proceedings of the National Academy of Sciences of the United States of America·Nelly PitteloudW F Crowley
Oct 26, 2007·Proceedings of the National Academy of Sciences of the United States of America·Nelly PitteloudW F Crowley
Nov 1, 1987·The Journal of Pediatrics·C Van DopM M Grumbach
Aug 1, 1981·International Journal of Andrology·A V HirshW P Collins
Jun 1, 1984·International Journal of Andrology·S J Winters
Apr 1, 1983·American Journal of Medical Genetics·H A GardnerM A MacKenzie
Feb 1, 1987·American Journal of Medical Genetics·I H PawlowitzkiP Miny
Dec 23, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yaguang ZhaoJia-Da Li
Nov 9, 2006·The Journal of Clinical Endocrinology and Metabolism·Annamaria De BellisAntonio Bellastella
Jul 1, 1986·Journal of Andrology·A Bauman
Apr 1, 1978·Journal of Endocrinological Investigation·A R GenazzaniP Fioretti
Mar 1, 1995·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·K B Horwitz, B Z Izenstein

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