Clinical and magnetic resonance image correlation in idiopathic cerebellar ataxia

Journal of the Neurological Sciences
K AbeT Yanagihara

Abstract

Sixty-one patients who fulfilled the clinical criteria for idiopathic cerebellar ataxia and who had symptoms at least for 3 years were examined clinically and by magnetic resonance imaging (MRI). Based on the clinical signs, they were divided into patients with pure cerebellar signs (Group 1), patients with additional mild rigidity and/or hyperreflexia (Group 2) and patients with additional severe rigidity and hypokinesia (Group 3). Patients in Group 1 had milder disability and better prognosis than patients in Group 2 or Group 3 (ataxic score: 14.9 vs. 28.6 and 36.0; annual progression ratio: 0.26 vs. 0.65 and 0.70, respectively). We measured the area of the cerebellar vermis, ventral pons and dorsal brainstem on midsagittal T1-weighted MR images for all patients and age- and sex-matched controls. The cerebellar vermis as well as the ventral pons of patients were significantly smaller than corresponding structures in controls (p < 0.001). The ventral pons of patients in Group 2 and Group 3 was significantly smaller than that of patients in Group 1 (p < 0.0001, respectively), and the dorsal brainstem of patients in Group 2 and Group 3 was also significantly smaller than that of patients in Group 1 (p < 0.001, respectively). The...Continue Reading

References

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Citations

Sep 7, 2000·Brain Research Bulletin·K AbeT Yanagihara
Feb 18, 2006·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Kazuo AbeSaburo Sakoda
Apr 20, 1999·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·H TerakawaT Yanagihara

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