Clinical and Magnetic Resonance Imaging Findings of Neurotoxocariasis

Frontiers in Neurology
Sofia S SánchezAlessandra Nicoletti

Abstract

Human toxocariasis is one of the most prevalent helminthiases worldwide.Toxocara canislarvae can cross the blood-brain barrier leading to the neurotoxocariasis. The clinical presentation consists of a wide spectrum of neurological manifestations, but asymptomatic infection is probably common. Neurotoxocariasis is not a frequent diagnosis probably due to the non-specific nature of its symptoms as well as the lack of confirmatory diagnostic tests. Diagnosis of neurotoxocariasis is based on the presence of a high titer of anti-Toxocaraantibody in the cerebrospinal fluid or in the serum, presence of eosinophilia in the serum or cerebrospinal fluid, and clinical and radiological improvement after anthelmintic therapy; however, universally accepted diagnostic criteria are lacking. Magnetic resonance imaging (MRI) findings include single or multiple, subcortical, cortical or white matter hyperintense lesions, best visualized on FLAIR and T2-weighted imaging, and usually isointense or hypointense on T1. These imaging findings are suggestive but not specific to neurotoxocariasis. Definitive diagnosis is made by histological confirmation, but it is rarely followed. This review provides an overview of the clinical manifestations, manageme...Continue Reading

References

Mar 1, 1979·Journal of Clinical Pathology·D H de SavignyA W Woodruff
Feb 23, 1978·The New England Journal of Medicine·P M Schantz, L T Glickman
Apr 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·P Rüttinger, H Hadidi
Jan 1, 1987·Scandinavian Journal of Infectious Diseases·M R TaylorH Smith
Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·I R HillC L Scholtz
May 1, 1974·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·N Z MikhaelM T Richard
Jan 1, 1966·The Journal of Pathology and Bacteriology·W BeautymanA L Woolf
Jan 1, 1981·Epidemiologic Reviews·L T Glickman, P M Schantz
Aug 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·A KomiyamaK Kondo
Feb 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·C SommerW M Glöckner
Jan 1, 1994·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·S B ZachariahR Varghese
Nov 1, 1996·Neuroradiology·T P DuprezM Buysschaert
Jan 3, 2001·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S GoffetteC J Sindic
Apr 1, 1962·Journal of Neuropathology and Experimental Neurology·M T MOORE
Apr 20, 2004·Revista Da Sociedade Brasileira De Medicina Tropical·Sandra F Moreira-SilvaFausto E L Pereira
May 13, 2004·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Heidi BächliOtmar Gratzl
Jun 2, 2005·La Revue de médecine interne·R MrissaS Othmani
Jul 19, 2005·Clinical Neurology and Neurosurgery·O EberhardtJ Dichgans
Oct 4, 2005·Journal of Neurology·Valérie Dauriac-Le MassonCharles Pierrot-Deseilligny
Nov 30, 2005·Journal of Neuro-oncology·Askin GorguluOmer Tural
Jul 4, 2006·Journal of the Neurological Sciences·Fujio UmeharaMitsuhiro Osame
Jan 16, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R HelbokE Schmutzhard
Sep 29, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Alefia MoiyadiSusarla Krishna Shankar
Nov 21, 2007·Revista Do Instituto De Medicina Tropical De São Paulo·Josef Finsterer, Herbert Auer
Jul 31, 2008·The Pediatric Infectious Disease Journal·Merle KellerCarrie L Byington
Apr 16, 2009·Clinical Microbiology Reviews·Carlos Graeff-TeixeiraKentaro Yoshimura
May 19, 2009·European Journal of Radiology·In Ho LeeHong Sik Byun
Dec 2, 2009·Journal of Korean Medical Science·Jin-Young LeeDong-Chull Choi
Feb 13, 2010·Annals of Tropical Medicine and Parasitology·G Rubinsky-ElefantM U Ferreira
Apr 10, 2010·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Kaede V OtaHelen S L Chan
Nov 6, 2010·Journal of Neurology·Oliver C SingerHelmuth Steinmetz
Jun 2, 2011·Case Reports in Medicine·Gregory HelsenLudo J Vanopdenbosch
Mar 20, 2012·Clinical Neurology and Neurosurgery·Jiro FukaeNobutaka Hattori
May 26, 2012·Revue neurologique·L-D LompoT Moulin
Aug 21, 2012·PLoS Neglected Tropical Diseases·Graziella QuattrocchiPierre-Marie Preux
Nov 8, 2012·Journal of Korean Neurosurgical Society·Cheon Wook ParkYoung Il Chun
Jan 16, 2013·Veterinary Parasitology·J Fillaux, J-F Magnaval
Apr 10, 2013·Journal of the Neurological Sciences·Jae-Hwan ChoiKwang-Dong Choi
Jul 9, 2013·Handbook of Clinical Neurology·Alessandra Nicoletti
Dec 24, 2014·Case Reports in Neurology·Christian Sick, Michael G Hennerici
Mar 4, 2015·Open Forum Infectious Diseases·Jean-Marc Fellrath, Jean-François Magnaval
Jun 13, 2015·Clinical Microbiology Reviews·Chia-Kwung FanUrsula Barghouth

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Citations

May 21, 2020·The American Journal of Tropical Medicine and Hygiene·Alessandra Nicoletti For The Cysticercosis Working Group In Peru
Jul 25, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Alessandra NicolettiMario Zappia
Jun 14, 2018·Infectious Diseases of Poverty·Jia ChenHany M Elsheikha
Jul 22, 2018·PLoS Neglected Tropical Diseases·Jaime LunaPierre-Marie Preux
Jan 22, 2020·Acta Parasitologica·Maria MeliouEleni Agapiou
Feb 18, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Kang-Po LeeChia-Kwung Fan
May 26, 2020·Seminars in Ultrasound, CT, and MR·Valerie L Jewells, Richard E Latchaw
Dec 2, 2020·Revue neurologique·L LegrisO Casez
May 19, 2021·Journal of Travel Medicine·Guillaume FaureThomas Papo

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Methods Mentioned

BETA
ELISA
biopsy
PCR

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