Clinical and microbiologic characteristics of tcdA-negative variant Clostridium difficile infections.

BMC Infectious Diseases
Jieun KimJung Oak Kang

Abstract

The tcdA-negative variant (A-B+) of Clostridium difficile is prevalent in East Asian countries. However, the risk factors and clinical characteristics of A-B+C. difficile infections (CDI) are not clearly documented. The objective of this study was to investigate these characteristics. From September 2008 through January 2010, the clinical characteristics, medication history and treatment outcomes of CDI patients were recorded prospectively. Toxin characterization and antibiotic susceptibility tests were performed on stool isolates of C. difficile. During the study period, we identified 22 cases of CDI caused by tcdA-negative tcdB-positive (A-B+) strains and 105 cases caused by tcdA-positive tcdB-positive (A+B+) strains. There was no significant difference in disease severity or clinical characteristics between the two groups. Previous use of clindamycin and young age were identified as significant risk factors for the acquisition of A-B+ CDI (OR = 4.738, 95% CI 1.48-15.157, p = 0.009 and OR = 0.966, 95% CI 0.935-0.998, p = 0.038, respectively) in logistic regression.Rates of resistance to clindamycin were 100% and 69.6% in the A-B+ and A+B+ isolates, respectively (p = 0.006), and the ermB gene was identified in 17 of 21 A-B+ is...Continue Reading

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Citations

Jul 3, 2013·Antimicrobial Resistance and Infection Control·Deirdre A CollinsThomas V Riley
May 25, 2013·PloS One·Anthony M BuckleyGillian R Douce
May 16, 2014·Acta Biochimica Et Biophysica Sinica·Ting ZhuLifeng Yang
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Dec 18, 2013·Journal of Medical Microbiology·Yun-Bo ChenLan-Juan Li
May 30, 2019·Emerging Microbes & Infections·Korakrit ImwattanaThomas V Riley
Jun 9, 2018·Anaerobe·Francisco A UzalBruce A McClane

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

SPSS

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