Clinical and microbiological changes associated with the use of combined antimicrobial therapies to treat "refractory" periodontitis

Journal of Clinical Periodontology
A D HaffajeeS S Socransky

Abstract

The present investigation examined clinical and microbial changes after a combined aggressive antimicrobial therapy in subjects identified as "refractory" to conventional periodontal therapy. Fourteen subjects were identified as "refractory" based on full-mouth mean attachment loss and/or >3 sites with attachment loss > or =3 mm following scaling and root planing (SRP), periodontal surgery and systemic antibiotics. After baseline monitoring, subjects received SRP, locally delivered tetracycline at pockets > or =4 mm, systemically administered amoxicillin (500 mg, t.i.d. for 14 days)+metronidazole (250 mg, t.i.d. for 14 days) and professional removal of supragingival plaque weekly for 3 months. Subjects were monitored clinically every 3 months post-therapy for 2 years. Subgingival plaque samples were taken at the same time points from the mesial aspect of each tooth and the levels of 40 subgingival taxa were determined using checkerboard DNA-DNA hybridization. Mean levels of each species were averaged within a subject at each visit. Significance of changes in clinical and microbiological parameters over time were evaluated using the Friedman or Wilcoxon signed ranks test. On average, subjects showed significant improvements in a...Continue Reading

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Citations

Jul 22, 2008·Applied and Environmental Microbiology·Morten EnersenDominique A Caugant
Jun 1, 2006·Journal of Periodontology·David M KimJoseph P Fiorellini
Oct 7, 2008·Journal of Periodontology·Ugo CovaniClaudio Nicolini
Mar 31, 2010·Journal of Periodontology·Bernd W SiguschJuliane Schütze
Mar 11, 2010·Journal of Periodontology·Emine Cifcibasi YekAlpdogan Kantarci
Dec 30, 2010·Journal of Periodontology·Simone MarconciniClaudio Nicolini
May 19, 2009·International Journal of Medical Microbiology : IJMM·Giuseppe ValenzaUlrich Vogel
Sep 2, 2005·Periodontology 2000·G Rutger Persson
Aug 26, 2006·Periodontology 2000·Ricardo P TelesSigmund S Socransky
Aug 26, 2006·Periodontology 2000·Anne D HaffajeeSigmund S Socransky
May 4, 2007·Periodontology 2000·Georgia K Johnson, Janet M Guthmiller
May 24, 2008·Journal of Clinical Periodontology·Øystein Fardal, Gerard James Linden
Sep 8, 2011·Journal of Periodontal Research·F R TelesA D Haffajee
Nov 29, 2012·Journal of Investigative and Clinical Dentistry·Tung Nguyen-Hieu
Apr 3, 2016·The Journal of the American Dental Association·Rayane S SantosCarlos F M Sarmento
Sep 14, 2016·Journal of Periodontology·Martin LevineRicardo P Teles
Mar 31, 2020·Proteomics. Clinical Applications·David GreenwoodGeorgios N Belibasakis
Nov 6, 2018·Journal of Dental Research·Z ZhuangC Sfeir
Mar 7, 2021·Microorganisms·Maigualida CuencaDavid Herrera
Aug 26, 2017·Microbiology Spectrum·Anilei HoarePatricia I Diaz

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