PMID: 8583019Aug 1, 1995Paper

Clinical and microbiological changes associated with the use of 4 adjunctive systemically administered agents in the treatment of periodontal infections

Journal of Clinical Periodontology
A D HaffajeeS S Socransky

Abstract

The purpose of the present investigation was to assess the effects of periodontal surgery and 4 systemically administered agents, Augmentin, tetracycline, ibuprofen or a placebo on clinical and microbiological parameters of periodontal disease. 98 subjects were monitored at 2-month intervals at 6 sites per tooth for clinical parameters. Subgingival plaque samples were taken from the mesial surface of each tooth at each visit and evaluated for their content of 14 subgingival species using DNA probes and a colony lift method. 40 subjects who exhibited loss of attachment > 2.5 mm at 1 or more sites during longitudinal monitoring were treated using modified Widman flap surgery at sites with probing pocket depth > 4 mm, subgingival scaling at all other sites and were randomly assigned 1 of the 4 agents. Treatment was completed within 30 days during which time the subject took the assigned agent. Overall, subjects exhibited a mean attachment level "gain" of 0.34 +/- 0.10 mm (SEM) and a mean pocket depth reduction of 0.62 +/- 0.09 mm 10 +/- 4 months post-therapy. However, certain subjects in each treatment group showed a poor response. Subjects receiving antibiotics exhibited significantly more attachment level "gain" (0.57 +/- 0.15 m...Continue Reading

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Citations

May 15, 2001·Journal of Clinical Periodontology·G SerinoJ Lindhe
Jan 6, 2001·Journal of Clinical Periodontology·A Drouganis, R Hirsch
Jan 6, 2001·Journal of Clinical Periodontology·I G NeedlemanN V Pandya
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Nov 1, 1996·Annals of Periodontology·K G Palcanis
Mar 1, 1997·Annals of Periodontology·S OffenbacherR C Williams
Mar 1, 2000·Journal of Periodontology·N J LópezB Martinez
Jan 7, 2005·Journal of Periodontology·Jørgen Slots, UNKNOWN Research, Science and Therapy Committee
Sep 21, 2005·Journal of Periodontology·M Robert WirthlinCharles I Hoover
Jan 2, 2008·Journal of Periodontology·C Alec YenAthena S Papas
Sep 6, 2008·Journal of Periodontology·Maria Cecília F AzoubelGerly Anne C Brito
Jan 12, 2010·Journal of Periodontology·Raphaël MoëneAndrea Mombelli
May 30, 2014·Journal of Indian Society of Periodontology·Rosh Radhika MohanDeepika Jayaprakash
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Sep 1, 2005·Journal of Clinical Periodontology·Giovanni E Salvi, Niklaus P Lang
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Jan 12, 2007·Periodontology 2000·Keith L KirkwoodWilliam V Giannobile
Aug 26, 2006·Periodontology 2000·Ricardo P TelesSigmund S Socransky
Sep 9, 2008·Journal of Clinical Periodontology·David HerreraMariano Sanz
Aug 11, 2006·Journal of Clinical Periodontology·Argelia Almaguer-FloresLaurie-Ann Ximenez-Fyvie
Sep 7, 2007·Oral Microbiology and Immunology·M J Sedlacek, C Walker

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